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Microwave assisted facile synthesis of amino acid benzyl ester p-toluenesulfonate and hydrochloride salts

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Abstract

A simple method for the synthesis of several amino acidbenzyl ester p-toluenesulfonate salts from thecorresponding amino acid and benzyl alcohol in presence of p-toluenesulfonic acid accelerated with microwave irradiation isdescribed. Under similar condition, the amino acid benzyl esterhydrochloride salts have also been obtained by using thionylchloride instead of p-toluenesulfonic acid in good yieldand purity.

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Authors and Affiliations

  1. Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore, 560 001, India

    Ganga-Ramu Vasanthakumar, Basanagoud S. Patil & Vommina Venkata Suresh Babu

Authors
  1. Ganga-Ramu Vasanthakumar
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  2. Basanagoud S. Patil
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  3. Vommina Venkata Suresh Babu
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Correspondence to Vommina Venkata Suresh Babu.

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Vasanthakumar, GR., Patil, B.S. & Babu, V.V.S. Microwave assisted facile synthesis of amino acid benzyl ester p-toluenesulfonate and hydrochloride salts. Letters in Peptide Science 9, 207–209 (2002). https://doi.org/10.1023/A:1024198717726

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