Skip to main content
SpringerLink
Log in

Delayed Effect of Antileukemic Polychemotherapy on Cell Death and Proliferation during Remission of Acute Lymphoblastic Leukemia in Children

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of programmed antileukemic drug therapy on cells of the tumor clone is not selective, and the drugs affect also intact bone marrow and peripheral blood cells. The cytotoxic effect of antitumor therapy is attained through triggering apoptosis and does not depend on the type of drug therapy. The treatment induces long-lasting changes in spontaneous cell death processes. The disturbances in the kinetics of cell death caused by drug therapy are compensated by changes in proliferative activity of bone marrow cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. A. Yu. Baryshnikov, E. R. Polosukhina, Yu. V. Shishkin, et al., Gematol. Transfuziol., 43,No. 2, 8–10 (1998).

    Google Scholar 

  2. T. E. Byukhner, Probl. Gematol. Perelivaniya Krovi, No. 3, 36–41 (1996).

  3. E. B. Vladimirskaya, N. S. Kislyak, and A. G. Rumyantsev, Gematol. Transfuziol., 43,No. 5, 3–8 (1998).

    Google Scholar 

  4. E. B. Vladimirskaya, I. B. Mazo, and N. V. Zamaraeva, Childhood Hematology, Oncology, Immunology [in Russian], Moscow (1994), pp. 165–175.

  5. K. S. Kaznacheev, Gematol. Transfuziol., 44,No. 1, 40–43 (1999).

    Google Scholar 

  6. K. S. Kaznacheev, Byull. Eksp. Biol. Med., 134,No. 11, 551–554 (2002).

    Google Scholar 

  7. A. I. Karachunskii, E. G. Kravchenko, A. Shtakel'berg, et al., Gematol. Transfuziol., 42,No. 5, 14–17 (1997).

    Google Scholar 

  8. Detection of Apoptotic Cells Using the Fluorescent Technique, FACS Lab., Promega Notes Magazine, No. 57, 10–23 (1996).

  9. Y. Hannun, Blood, 89,No. 6, 1845–1853 (1997).

    Google Scholar 

  10. S. Lennon, S. Martin, and T. Gotter, Cell Prolif., 24, 203–214 (1991).

    Google Scholar 

  11. D. J. McConkey and S. Orrenius, Trends Cell Biol., No. 4, 370 (1994).

  12. C. B. Thompson, Science, 267, 1456–1458 (1995).

    Google Scholar 

  13. J.-P. Vial and F. Belloct, Leukemia Res., 21, 163–172 (1996).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Siberian Division of Russian Academy of Medical Sciences, Laboratory of Molecular Cellular and Immunomorphological Bases of Oncohematology, Institute of Regional Pathology and Pathomorphology, Novosibirsk

    K. S. Kaznacheev

  2. Ministry of Health of Russian Federation, Institute of Pediatric Hematology, Moscow

    K. S. Kaznacheev

Authors
  1. K. S. Kaznacheev
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaznacheev, K.S. Delayed Effect of Antileukemic Polychemotherapy on Cell Death and Proliferation during Remission of Acute Lymphoblastic Leukemia in Children. Bulletin of Experimental Biology and Medicine 135, 281–284 (2003). https://doi.org/10.1023/A:1024197317286

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1024197317286

Search

Navigation