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CASE REPORT: A Rare Manifestation of Behçet's Syndrome: Immunological Correlates and Successful Treatment of an Esophageal Ulcer

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References

  1. Adamantiades B: Sur un cas d'iritis a hypopyon recidivant. Oculist 138:271-278, 1931

    Google Scholar 

  2. Behcet H: über rezidivierende, aphtöse Geschwüre im Mund, Auge und an den Genitalien. Dtsch Med Wochenschr 105:1152-1157, 1937

    Google Scholar 

  3. Sakane T, Takeno M, Suzuki N, Inaba G: Behcet's disease. N Engl J Med 341:1284-1291, 1999

    Google Scholar 

  4. International Study Group for Behcet's Disease: Criteria for diagnosis of Behcet's disease. Lancet 335:1078-1080, 1990

  5. Duhrsen U, Kirch W: Diagnosis of Behcet's syndrome. Dtsch Med Wochenschr 110:264-267, 1985 (in German)

    Google Scholar 

  6. Zouboulis CC: Epidemiology of Adamantiades-Behcet's disease. Ann Med Intern (Paris) 150:488-498, 1999

    Google Scholar 

  7. Zouboulis CC, Kotter I, Djawari D, Kirch W, Kohl PK, Ochsendorf FR, Keitel W, Stadler R, Wollina U, Proksch E, Sohnchen R, Weber H, Gollnick HP, Holzle E, Fritz K, Licht T, Orfanos CE: Epidemiological features of Adamantiades-Behcet's disease in Germany and in Europe. Yonsei Med J 38:411-422, 1997

    Google Scholar 

  8. Mizuki N, Inoko H, Ohno S: Pathogenic gene responsible for the predisposition of Behcet's disease. Int Rev Immunol 14:33-48, 1997

    Google Scholar 

  9. Tabata M, Tomomasa T, Kaneko H, Morikawa A: Intestinal Behcet's disease: a case report and review of Japanese reports in children. J Pediatr Gastroenterol Nutr 29:477-481, 1999

    Google Scholar 

  10. Lehmann H, Stutte HJ, Zierott G, Schlaak M: A case of Behcet's disease with multiple intestinal ulcerations Dtsch Med Wochenschr 100:308-311, 1975 (in German author's transl)

    Google Scholar 

  11. Arma S, Habibulla KS, Price JJ, Collis JL: Dysphagia in Behcet's syndrome. Thorax 26:155-158, 1971

    Google Scholar 

  12. Mori S, Yoshihira A, Kawamura H, Takeuchi A, Hashimoto T, Inaba G. Esophageal involvement in Behcet's disease. Am J Gastroenterol 78:548-553, 1983

    Google Scholar 

  13. Yashiro K, Nagasako K, Hasegawa K, Maruyama M, Suzuki S, Obata H: Esophageal lesions in intestinal Behcet's disease. Endoscopy 18:57-60, 1986

    Google Scholar 

  14. Ikezawa K, Kashimura H, Hassan M, Nakahara A, Yanaka A, Matsuzaki Y, et al: A case of Behcet's syndrome with esophageal involvement treated with salicylazosulfapyridine and prednisolone. Endoscopy 30:S52-S53, 1998

    Google Scholar 

  15. Lorenzetti ME, Forbes IJ, Roberts-Thomson IC: Oesophageal and ileal ulceration in Behcet's disease. J Gastroenterol Hepatol 5:714-717, 1990

    Google Scholar 

  16. Glosemeyer R, Deppe H, Dormann AJ, Wigginghaus B, Stolte M, Stadler R, et al: Ulcerative esophagitis and colitis as rare manifestations of Adamantiades-Behcet disease. Z Gastroenterol 39:167-171, 2001 (in German)

    Google Scholar 

  17. Reimer G, Luckner L, Hornstein OP: Direct immunofluorescence in recurrent aphthous ulcers and Behcet's disease. Dermatologica 167:293-298, 1983

    Google Scholar 

  18. Savage NW, Mahanonda R, Seymour GJ, Bryson GJ, Collins RJ: The proportion of suppressor-inducer T-lymphocytes is reduced in recurrent aphthous stomatitis. J Oral Pathol 17:293-297, 1988

    Google Scholar 

  19. Eksioglu-Demiralp E, Direskeneli H, Ergun T, Fresko I, Akoglu T: Increased CD4+CD16+ and CD4+CD56+ T cell subsets in Behcet's disease. Rheumatol Int 19:23-26, 1999

    Google Scholar 

  20. Hamza M, Makni S: Secretory component deficiency in Behcet's disease. Clin Rheumatol 14:227-228, 1995

    Google Scholar 

  21. Emmi L, Brugnolo F, Salvati G, Marchione T: Immunopathological aspects of Behcet's disease. Clin Exp Rheumatol 13:687-691, 1995

    Google Scholar 

  22. Mege JL, Dilsen N, Sanguedolce V, Gul A, Bongrand P, Roux H, Ocal L, Inanc M, Capo C: Overproduction of monocyte derived tumor necrosis factor alpha, interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Behcet's disease. A comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol 20:1544-1549, 1993

    Google Scholar 

  23. Freitas JP, Filipe P, Yousefi A, Emerit I, Guerra RF: Oxidative stress in Adamantiades-Behcet's disease. Dermatology 197:343-348, 1998

    Google Scholar 

  24. Hamzaoui K, Hamza M, Ayed K: Production of TNF-alpha and IL-1 in active Behcet's disease. J Rheumatol 17:1428-1429, 1990

    Google Scholar 

  25. Freysdottir J, Lau S, Fortune F: Gammadelta T cells in Behcet's disease (BD) and recurrent aphthous stomatitis (RAS). Clin Exp Immunol 118:451-457, 1999

    Google Scholar 

  26. Yamashita N, Kaneoka H, Kaneko S, Takeno M, Oneda K, Koizumi H, Kogure M, Inaba G, Sakane T: Role of gammadelta T lymphocytes in the development of Behcet's disease. Clin Exp Immunol 107:241-247, 1997

    Google Scholar 

  27. Doherty DG, Norris S, Madrigal-Estebas L, McEntee G, Traynor O, Hegarty JE, O'Farrelly C: The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns. J Immunol 163:2314-2321, 1999

    Google Scholar 

  28. Hamza M, Elleuch M, Slim A, Hamzaoui K, Ayed K: Antibodies to herpes simplex virus in patients with Behcet's disease. Clin Rheumatol 9:498-500, 1990

    Google Scholar 

  29. Sohn S, Lee ES, Bang D, Lee S: Behcet's disease-like symptoms induced by the herpes simplex virus in ICR mice. Eur J Dermatol 8:21-23, 1998

    Google Scholar 

  30. Hamzaoui K, Kahan A, Ayed K, Hamza M: Cytotoxic T cells against herpes simplex virus in Behcet's disease. Clin Exp Immunol 81:390-395, 1990

    Google Scholar 

  31. Lehner T: The role of heat shock protein, microbial and autoimmune agents in the aetiology of Behcet's disease. Int Rev Immunol 14:21-32, 1997

    Google Scholar 

  32. Namba K, Ueno T, Matsumi F, Okita M, Yumita A, Fujino Y, Fujie W: Behcet's disease and Streptococcus infection. Time course of titer of streptococcal antigen and comparison with other uveitis. Nippon Ganka Gakkai Zasshi 89:200-207, 1985 (in Japanese)

    Google Scholar 

  33. Isogai E, Ohno S, Kotake S, Isogai H, Tsurumizu T, Fujii N, Yokota K, Syuto B, Yamaguchi M, Matsuda H: Chemiluminescence of neutrophils from patients with Behcet's disease and its correlation with an increased proportion of uncommon serotypes of Streptococcus sanguis in the oral flora. Arch Oral Biol 35:43-48, 1990

    Google Scholar 

  34. Zouboulis CC, Orfanos CE: Treatment of Adamantiades-Behcet disease with systemic interferon alfa. Arch Dermatol 134:1010-1016, 1998

    Google Scholar 

  35. Hamuryudan V, Moral F, Yurdakul S, Mat C, Tuzun Y, Ozyazgan Y, Direskeneli H, Akoglu T, Yazici H: Systemic interferon alpha 2b treatment in Behcet's syndrome. J Rheumatol 21:1098-1100, 1994

    Google Scholar 

  36. Sakane T, Takene M: Interferon therapy in Behcet's disease. Intern Med 39:604-605, 2000

    Google Scholar 

  37. Kotter I, Durk H, Saal J, Fierlbeck G, Pleyer U, Ziehut M: Therapy of Behcet's disease. Ger J Ophthalmol 5:92-97, 1996

    Google Scholar 

  38. Yazici H, Pazarli H, Barnes CG, Tuzun Y, Ozyazgan Y, Silman A, Serdaroglu S, Oguz V, Yurdakul S, Lovatt GE: A controlled trial of azathioprine in Behcet's syndrome. N Engl J Med 322:281-285, 1990

    Google Scholar 

  39. Hamuryudan V, Ozyazgan Y, Hizli N, Mat C, Yurdakul S, Tuzun Y, Senocak M, Yazici H: Azathioprine in Behcet's syndrome: effects on long-term prognosis. Arthritis Rheum 40:769-774, 1997

    Google Scholar 

  40. Ozyazgan Y, Yurdakul S, Yazici H, Tuzun B, Iscimen A, Tuzun Y, Aktunc T, Pazarli H, Hamuryudan V, Muftuoglu A: Low dose cyclosporin A versus pulsed cyclophosphamide in Behcet's syndrome: a single masked trial. Br J Ophthalmol 76:241-243, 1992

    Google Scholar 

  41. Diaz-Llopis M, Cervera M, Menezo JL: Cyclosporin A treatment of Behcet's disease: a longterm study. Curr Eye Res 9(supp):17-23, 1990

    Google Scholar 

  42. Park JY, Park JG, Won JH, Lee JM, Kim NS, Jung TH: Effects of corticosteroid and chlorambucil on multiple pulmonary artery aneurysms in Behcet's syndrome. A case report. J Korean Med Sci 10:470-473, 1995

    Google Scholar 

  43. Simsek I, Dinc A, Mas MR, Gunhan O, Kocabalkan F: Behcet's disease with a cecal perforation. Clin Exp Rheumatol 18:268-269, 2000

    Google Scholar 

  44. Yurdakul S, Mat C, Tuzun Y, Ozyazgan Y, Hamuryudan V, Uysal O, Senocak M, Yazici H: A double-blind trial of colchicine in Behcet's syndrome. Arthritis Rheum 44:2686-2692, 2001

    Google Scholar 

  45. Hamuryudan V, Mat C, Saip S, Ozyazgan Y, Siva A, Yurdakul S, Zwingenberger K, Yazici H: Thalidomide in the treatment of the mucocutaneous lesions of the Behcet syndrome. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 128:443-450, 1998

    Google Scholar 

  46. Ranselaar CG, Boone RM, Kluin-Nelemans, HC: Thalidomide in the treatment of neuro-Behcet's syndrome. Br J Dermatol 115:367-370, 1986

    Google Scholar 

  47. Hamza M, Hamzaoui K, Ayed K: Treatment of Behcet's disease with dapsone. Clin Rheumatol 8:113-114, 1989

    Google Scholar 

  48. Hisamatsu T, Kishikawa H, Fukuya H, Matsuoka K, Mizuno Y, Nishida J: Combination therapy including pentoxifylline for entero-Behcet's disease. Bull Tokyo Dent Coll 42:169-176, 2001

    Google Scholar 

  49. Hamuryudan V, Ozyazgan Y, Yazici H: Treatment of Bechet disease with pentoxifylline. Ann Intern Med 126:493, 1997

    Google Scholar 

  50. Sonta T, Araki Y, Koubokawa M, Tamura Y, Ochiai T, Harada N, Chijiiwa Y, Nawata H: The beneficial effect of mesalazine on esophageal ulcers in intestinal Behcet's disease. J Clin Gastroenterol 30:195-199, 2000

    Google Scholar 

  51. Lee KS, Kim SJ, Lee BC, Yoon DS, Lee WJ, Chi HS: Surgical treatment of intestinal Behcet's disease. Yonsei Med J 38:455-460, 1997

    Google Scholar 

  52. Sakane T, Takeno M: Novel approaches to Behcet's disease. Expert Opin Investig Drugs 9:1993-2005, 2000

    Google Scholar 

  53. Hassard PV, Binder SW, Nelson V, Vasiliauskas EA: Anti-tumor necrosis factor monoclonal antibody therapy for gastrointestinal Behcet's disease: a case report. Gastroenterology 120:995-999, 2001

    Google Scholar 

  54. Travis SP, Czajkowski M, McGovern DP, Watson RG, Bell AL: Treatment of intestinal Behcet's syndrome with chimeric tumour necrosis factor alpha antibody. Gut 49:725-728, 2001

    Google Scholar 

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Wedemeyer, H., Kuipers, J.G., Streetz, K. et al. CASE REPORT: A Rare Manifestation of Behçet's Syndrome: Immunological Correlates and Successful Treatment of an Esophageal Ulcer. Dig Dis Sci 48, 1385–1391 (2003). https://doi.org/10.1023/A:1024183931726

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