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Longitudinal Study of Bone Mineral Density in Patients with Crohn's Disease

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Abstract

Osteoporosis is frequent in Crohn's disease. The aim of the study was to assess the rate of bone loss over time retrospectively and the influence of disease-related factors on bone loss. Twenty-nine patients (8 male), admitted for repeated bone mineral density assessments (BMD) were enrolled. BMD measured by dual energy x-ray absoptiometry was expressed in grams per square centimeter, and as sex- and age-matched Z score. The mean interval between BMD assessments was 41 months, during which period 27 patients used corticosteroids (mean dose 8.6 g) and 21 patients some form of bone protective medication. Initial Z scores at a mean age of 41 years were significantly below zero (spine −1.6 ± 1.4; femur −1.4 ± 1.4). Over time, no change in absolute BMD was observed accompanied by an improvement in Z scores. At the same time, an increase in body weight and a decrease in erythrocyte sedimentation rate (ESR) was observed. Multilinear regression analysis demonstrated change in ESR as independent predictor for change in femoral Z score. In conclusion, low BMD is frequent in Crohn's disease, but decline of BMD over time was not found, despite ongoing use of corticosteroids.

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Authors
  1. D.J. De Jong
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  2. L. Mannaerts
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  3. L.G.M. van Rossum
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  4. F.H.M. Corstens
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  5. A.H.J. Naber
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De Jong, D., Mannaerts, L., van Rossum, L. et al. Longitudinal Study of Bone Mineral Density in Patients with Crohn's Disease. Dig Dis Sci 48, 1355–1359 (2003). https://doi.org/10.1023/A:1024171529000

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  • DOI: https://doi.org/10.1023/A:1024171529000

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