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Stress-Limiting Effect of Dehydroepiandrosterone Sulfate and Its Mechanism

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Abstract

Dehydroepiandrosterone sulfate prevented the increase in corticosterone level in rats induced by repeated exposure to stress. The μ-opioid receptor blocker naltrexone administered in a dose of 0.1 mg/kg 20 min before treatment with dehydroepiandrosterone sulfate abolished the effect of this agent. Dehydroepiandrosterone sulfate and naltrexone had no effect on rats after acute stress.

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Authors and Affiliations

  1. Siberian Division of the Russian Academy of Medical Sciences, Institute of Physiology, Novosibirsk

    T. A. Obut, M. V. Ovsyukova & O. P. Cherkasova

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  1. T. A. Obut
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  2. M. V. Ovsyukova
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  3. O. P. Cherkasova
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Correspondence to T. A. Obut.

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Obut, T.A., Ovsyukova, M.V. & Cherkasova, O.P. Stress-Limiting Effect of Dehydroepiandrosterone Sulfate and Its Mechanism. Bulletin of Experimental Biology and Medicine 135, 231–233 (2003). https://doi.org/10.1023/A:1024168510925

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