Abstract
A recent study by our group demonstrated that a 1-week infusion of insulin-like growth factor-I increases bile flow volume and bile acid secretion in rats, suggesting it is important in in vivo choleresis. In the present study, the effect in rats of a single administration of insulin-like growth factor-I on bile flow volume was investigated and compared with the choleretic drugs prednisolone and ursodeoxycholic acid. A significant and long-lasting increase in bile flow volume was observed in rats treated with insulin-like growth factor-I or prednisolone. Ursodeoxycholic acid significantly, but transiently increased. Combined treatment using insulin-like growth factor-I with prednisolone or ursodeoxycholic acid additively increased bile flow volume. Overall, this study demonstrated that the stimulatory effect of insulin-like growth factor-I on bile flow volume is almost equally potent to that of prednisolone and ursodeoxycholic acid, indicating the possible therapeutic potential of insulin-like growth factor-I in cholestatic liver diseases.
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Mabuchi, M., Kawamura, I., Fushimi, M. et al. Choleretic Actions of Insulin-Like Growth Factor-I, Prednisolone, and Ursodeoxycholic Acid in Rats. Dig Dis Sci 48, 1398–1405 (2003). https://doi.org/10.1023/A:1024140116705
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DOI: https://doi.org/10.1023/A:1024140116705