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Biogerontology

, Volume 4, Issue 3, pp 171–178 | Cite as

The intra-individual diversity in senescence

  • Sergey N. Rumyantsev
Article

Abstract

One of the most characteristic and widely observable features of senescence, usually ignored by scientific investigation, is a very variable, dapple distribution of its manifestations, seen within systems, organs, and tissues of the same individual. Different parts of an organ or tissue undergo senescence at different ages. The early aged foci may form only small solitary places in a tissue, an organ, a region, or an organism or in large parts of it. The proportion of early aged parts to later aged ones, as well as their localization, is predestined by individual genetic makeup, thus determining diversity in the course and forms of senile regression and the lifespan of organisms under consideration. It is a kind of biodiversity that is least known. To clear up what we can say about the nature of the phenomenon today, the features of this kind of human body diversity were interpreted using the data and conceptions of immunology, molecular biology and genetics. The results of the interpretation allow us to suppose that different parts of a human body usually have unequal genetic limits of life duration and their own programs of ageing; each of them has its own `biological watch' which tells a different time. The genesis of this diversity can be explained by hybridization of persons with different genetic susceptibility to internal and/or environmental factors inducing senescence.

ageing biodiversity genetics gerontology heterozygosity hybrid intra-individual diversity lifespan progeria 

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References

  1. Allard M, Lebre V and Calment J (1998) Jeanne Calment: From Van Gogh's Time to Ours: 122 Extraordinary Years. WH Freeman, New YorkGoogle Scholar
  2. Clark W (1996) Sex and the Origins of Death. Oxford University Press, New YorkGoogle Scholar
  3. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M and Campisi J (1995) A novel biomarker identifies senescent human cells in culture and aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367PubMedCrossRefGoogle Scholar
  4. Finch CE (1990) Senescence, Longevity, and the Genome. Chicago, IllinoisGoogle Scholar
  5. Finch CE and Kirkwood T (2001) Chance, Development and Aging. Oxford University Press, OxfordGoogle Scholar
  6. Friedman D and Johnson T (1988) A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118: 75-86PubMedGoogle Scholar
  7. Heatley RV (1998) The Helicobacter Pylori Handbook. Blackwell Science, OxfordGoogle Scholar
  8. Giacometty L (1965) Hair growth and aging. In: Montagna W (ed) Advances in the Biology of the Skin, pp 97-118. Pergamon Press, OxfordGoogle Scholar
  9. Huang S, Li B, Gray MD, Oshima J, Mian S and Campisi J (1998) The premature aging syndrome protein WRN is a 3′ to 5′ exonuclease. Nature Genetics 20: 114-116PubMedCrossRefGoogle Scholar
  10. Kligman AM, Grove GL and Balin AK (1985) Aging of human skin. In: Finch CE and Schneider EL (eds) Handbook of the Biology of Aging, pp 820-841. Van Nostrand Reinhold, New YorkGoogle Scholar
  11. Littleton J and Frohlich B (1993) Fish-eaters and farmers: dental pathology in the Arabian Gulf. Am J Phys Anthropol 92: 427-447PubMedCrossRefGoogle Scholar
  12. Macieira-Coelho A (1997) Genetics of aging. C R Seances Soc Biol Fil 191: 545-551PubMedGoogle Scholar
  13. McClintock B (1980) Modified gene expressions induced by transposable elements. In: Scott WA et al. (eds) Mobilization and Reassembly of Genetic Information, pp 11-19. Academic Press, New YorkGoogle Scholar
  14. Paxton WA, Martin SR, Tse D, O'Brien TR, Skumnick J, VanDevanter NL, Padian N, Braun JF, Kotler DP, Wolinsky SM and Koup RA (1996) Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected dispite multiple high-risk sexual exposure. Nat Med 2: 412PubMedCrossRefGoogle Scholar
  15. Purvis A and Hector A (2000) Getting the measure of biodiversity. Nature 405: 212-219PubMedCrossRefGoogle Scholar
  16. Rattan SIS (2000) Biogerontology: the next step. Molecular and cellular gerontology. Ann NY Acad Sci 908: 282-290PubMedCrossRefGoogle Scholar
  17. Robson HG and Vas SI (1972) Resistance of inbred mice to Salmonella typhimurium. J Infect Dis 126: 378-386PubMedGoogle Scholar
  18. Rotterdam H (1989) Pathology of the Stomach and Duodenum. Springer-Verlag, New YorkGoogle Scholar
  19. Rumyantsev SN (1992) Observations on constitutional resistance to infection. Immunol Today 13: 184-187PubMedCrossRefGoogle Scholar
  20. Rumyantsev SN (1998) Constitutional and nonspecific immunity to infection. Rev Sci Tech Off Int Epiz 17: 26-42Google Scholar
  21. Rumyantsev SN (2002) Structural predestination of individual diversity in the course and severity of infectious diseases. Sci World J 2: 205-216Google Scholar
  22. Rumyantsev SN, Shabalow NP, Pyasetskaya MF, Rogacheva NM and Bardakova LI (2000) Species, population and age diversity in cell resistance to adhesion of Neisseria meningitidis serogroups A, B and C. Microbes and Infection 2: 447-453PubMedCrossRefGoogle Scholar
  23. Semsei I (2000) On the nature of aging. Mech Ageing Dev 117: 93-108PubMedCrossRefGoogle Scholar
  24. Shock NW (1985) Longitudinal studies of aging in humans. In: Finch CE and Schneider EL (eds) Handbook of the Biology of Aging, pp 721-743. Van Nostrand Reinold, New YorkGoogle Scholar
  25. Sing SF and Moll PP (1990) Genetics of atherosclerosis. Annu Rev Genet 24: 171-187PubMedCrossRefGoogle Scholar
  26. Strehler B (1999) Time, Cells, and Aging. Cyprus Press, CyprusGoogle Scholar
  27. Thomas GA, Williams D and Williams ED (1988) The demonstration of tissue clonality by X-linked enzyme histochemistry. J Pathol 155: 101-108PubMedCrossRefGoogle Scholar
  28. Vavilov NI (1964) Immunity of Plants to Infectious Diseases. Nauka, Moscow/LeningradGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Sergey N. Rumyantsev
    • 1
  1. 1.Andent, IncWaukeganUSA

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