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Antimutagenic and Antioxidant Activities of Crown Compounds in Comparison with the Effects of Garlic Extract

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Abstract

Antimutagenic activity of N-carboxyalkyl derivatives of aza- and benzoazacrown compounds was revealed and antimutagenic activity of garlic extract was confirmed. Specific genoprotective effect of crown compounds towards the effects of various mutagens was demonstrated. The antimutagenic effect of these compounds was not realized via antioxidant mechanisms, while the protective effect of garlic extract was associated with its antioxidant and reparative activities.

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Authors and Affiliations

  1. Russian Academy of Sciences, Institute of General Genetics, Russia

    G. D. Zasukhina, I. M. Vasil'eva, E. S. Mikhal'chik, A. D. Durnev, S. P. Gromov, O. A. Fedorova & M. V. Alfimov

  2. Russian Academy of Medical Sciences, Institute of Pharmacology, Russia

    G. D. Zasukhina, I. M. Vasil'eva, E. S. Mikhal'chik, A. D. Durnev, S. P. Gromov, O. A. Fedorova & M. V. Alfimov

  3. Photochemistry Center, Russian Academy of Sciences, Moscow

    G. D. Zasukhina, I. M. Vasil'eva, E. S. Mikhal'chik, A. D. Durnev, S. P. Gromov, O. A. Fedorova & M. V. Alfimov

Authors
  1. G. D. Zasukhina
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  2. I. M. Vasil'eva
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  3. E. S. Mikhal'chik
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  4. A. D. Durnev
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  5. S. P. Gromov
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  6. O. A. Fedorova
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  7. M. V. Alfimov
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Zasukhina, G.D., Vasil'eva, I.M., Mikhal'chik, E.S. et al. Antimutagenic and Antioxidant Activities of Crown Compounds in Comparison with the Effects of Garlic Extract. Bulletin of Experimental Biology and Medicine 135, 261–264 (2003). https://doi.org/10.1023/A:1024137031398

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  • DOI: https://doi.org/10.1023/A:1024137031398

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