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Peculiarities of the Development of Analgesic Effect during Transcutaneous Dynamic Electrical Stimulation

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Abstract

The effect of transcutaneous dynamic electrical neurostimulation on the development of analgesia was studied in behavioral and electrophysiological experiments on rats. A 30-min dynamic electrical stimulation elevated the nociception threshold in tail-flick and hot plate tests, increased the threshold of the late nociceptive flexor reflex, and decreased the number of bursts in the response. Intraperitoneal injection of naloxone (2 mg/kg) abolished the analgesic effect of dynamic electrical neurostimulation. It is concluded that the key role in reflex analgesia during dynamic electrical neurostimulation is played by the endogenous cerebral opioid system, which inhibits the nociceptive signals traveling to CNS via unmyelinated C-fiber afferents.

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REFERENCES

  1. Yu. D. Ignatov, A. T. Kachan, and Yu. N. Vasil'ev, in: Acupunctural Analgesia: Experimental and Clinical Aspects [in Russian], Leningrad (1990).

  2. M. L. Kukushkin and V. K. Reshetnyak, Byull. Eksp. Biol. Med., 102,No. 11, 517–519 (1986).

    Google Scholar 

  3. E. E. Meizerov, I. M. Chernysh, and M. N. Dubova, Anest. Reanimatol., No. 4, 31–34 (2002).

  4. N. A. Osipova, G. A. Novikov, and B. M. Prokhorov, Chronic Pain Syndrome in Oncology [in Russian], Moscow (1998).

  5. S. S. Pavlenko, Nevrol. Zh., No. 1, 41–46 (1999).

  6. V. K. Reshetnyak, M. L. Kukushkin, and R. A. Durinyan, Byull. Eksp. Biol. Med., 96,No. 7, 14–16 (1983).

    Google Scholar 

  7. J. J. Bonica, The Management of Pain, 2nd ed., Philadelphia (1990).

  8. X.-H. Chen and J.-S. Han, Behav. Brain Res., 47, 143–149 (1992).

    Google Scholar 

  9. L. S. Chesterson, P. Barlas, N. E. Foster, et al., Pain, 99,Nos. 1–2, 253–262 (2002).

    Google Scholar 

  10. S. Falinower, J.-C. Wilier, J.-L. Junien, D. Le Bars, J. Neurophysiol., 72,No. 1, 194–212 (1994).

    Google Scholar 

  11. C. Takeshige, Dt. Ztschr. Akupunktur, 2, 124–127 (2002).

    Google Scholar 

  12. J.-H. Tian, W. Zhang, Y. Fang, et al., Br. J. Pharmacol., 124, 21–26 (1998).

    Google Scholar 

  13. G. A. Ulett, S. Han, J.-S. Han, Biol. Psychiat., 44, 129–138 (1998).

    Google Scholar 

  14. Y. Wan, S. G. Wilson, J.-S. Han, J. S. Mogil, Pain, 91,Nos. 1–2, 5–13 (2001).

    Google Scholar 

  15. W. D. Willis, in: Progress in Pain Research and Management, Eds. G. F. Gebhart, et al., Vol. 2, Seattle (1994), pp. 301–324.

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Authors and Affiliations

  1. Russian Academy of Medical Sciences, Laboratory of Pain Pathophysiology, Institute of General Pathology and Pathological Physiology, Russia

    M. L. Kukushkin, E. E. Meizerov, V. N. Grafova, V. S. Smirnova, A. A. Gurov & V. V. Chernyshev

  2. Federal Scientific Clinical and Experimental Center of Traditional Diagnostic and Therapeutic Methods, Russian Ministry of Health, Research Institute of Reflex Therapy, Moscow

    M. L. Kukushkin, E. E. Meizerov, V. N. Grafova, V. S. Smirnova, A. A. Gurov & V. V. Chernyshev

Authors
  1. M. L. Kukushkin
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  2. E. E. Meizerov
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  3. V. N. Grafova
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  4. V. S. Smirnova
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  5. A. A. Gurov
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  6. V. V. Chernyshev
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Kukushkin, M.L., Meizerov, E.E., Grafova, V.N. et al. Peculiarities of the Development of Analgesic Effect during Transcutaneous Dynamic Electrical Stimulation. Bulletin of Experimental Biology and Medicine 135, 228–230 (2003). https://doi.org/10.1023/A:1024116526855

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  • DOI: https://doi.org/10.1023/A:1024116526855

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