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Mad dogs, Englishmen and apoptosis: The role of cell death in UV-induced skin cancer

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Abstract

Apoptosis plays a critical role in the development and progression of ultraviolet-induced skin cancers. In particular, Fas and Fas ligand (FasL) interactions are known to control the development of “sunburn cells” or apoptotic keratinocytes in the UV-exposed epidermis. In the absence of functional Fas/FasL signaling, UV-induced apoptosis is diminished and mutations rapidly accumulate. UV-induced suppression of host immunity, a process regulating skin cancer outgrowth, is also controlled through Fas/FasL interactions. Other death receptors, such as the receptor for tumor necrosis factor, may also contribute to UV-induced carcinogenesis and progression. Understanding the involvement of cell death in cancers caused by exposure to sunlight may provide novel approaches for prevention and therapy of these ever-increasing malignancies.

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  1. Department of Biomedical Sciences, The University of California-Riverside, Riverside, California, 92521, USA

    E. Guzman, J. L. Langowski & L. Owen-Schaub

  2. Graduate School of Biomedical Sciences, The University of Texas-Houston, Houston, Texas, 77030, USA

    E. Guzman & J. L. Langowski

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Guzman, E., Langowski, J.L. & Owen-Schaub, L. Mad dogs, Englishmen and apoptosis: The role of cell death in UV-induced skin cancer. Apoptosis 8, 315–325 (2003). https://doi.org/10.1023/A:1024112231953

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