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Is Replication of Hepatitis C Virus a Marker of Activity of Infectious Process? (Findings of Polymerase Chain Reaction and Morphological Analysis of Liver Biopsy Specimens)

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Abstract

Comparative study of replication markers of hepatitis C virus in various biological substrates and evaluation of activity of chronic HCV infection in liver biopsy specimens showed that replication of hepatitis C virus and the number of HCV-infected hepatocytes did not promote liver damage in chronic hepatitis C. These findings indicate that the expression of antiviral reactions by liver parenchyma cells plays the key role in the morphogenesis of HCV infection.

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Authors and Affiliations

  1. Laboratory of Ultrastructural Bases of Pathology, Laboratory of Clinical and Morphologic Bases of Infections Pathology, and Laboratory of Clinical Morphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk

    G. I. Nepomnyashchikh, N. P. Tolokonskaya, S. V. Aidagulova, D. L. Nepomnyashchikh, Yu. Yu. Karavaeva, E. G. Sakharova, G. A. Mezentseva & E. V. Batemirova

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  1. G. I. Nepomnyashchikh
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  2. N. P. Tolokonskaya
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  3. S. V. Aidagulova
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  4. D. L. Nepomnyashchikh
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  5. Yu. Yu. Karavaeva
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  6. E. G. Sakharova
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  7. G. A. Mezentseva
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  8. E. V. Batemirova
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Correspondence to G. I. Nepomnyashchikh.

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Nepomnyashchikh, G.I., Tolokonskaya, N.P., Aidagulova, S.V. et al. Is Replication of Hepatitis C Virus a Marker of Activity of Infectious Process? (Findings of Polymerase Chain Reaction and Morphological Analysis of Liver Biopsy Specimens). Bulletin of Experimental Biology and Medicine 135, 296–300 (2003). https://doi.org/10.1023/A:1024105619103

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