Abstract
The retention and separation of optical isomers of amino acid derivatives on aminated β-cyclodextrin was studied. The pH dependence of the distribution coefficients of these derivatives in the octanol–water system was found. It was demonstrated that the capacity factors and the enantioselectivity of the separation of amino acid derivatives depend on the hydrophobicity of the studied compounds.
Similar content being viewed by others
REFERENCES
Berthod, A., Jin, H.L., Beesley, T.E., Duncan, J.D., and Armstrong, D.W., J. Pharm. Biomed. Anal., 1990, vol. 8, no. 2, p. 123.
Allenmark, S.G., Chromatographic Enantioseparation: Methods and Applications, Chichester: Horwood, 1998. Translated under the title Khromatograficheskoe razdelenie enantiomerov, Moscow: Mir, 1991.
Williams, K.L., Sander, L.C., and Wise, S.A., J. Chromatogr., 1996, vol. 746, p. 91.
Armstrong, D.W., Hilton, M., and Coffin, L., LC–GC, 1991, vol. 9, no. 9, p. 646.
Armstrong, D.W., Chang, C.D., and Lee, S.H., J. Chromatogr., 1991, vol. 539, p. 83.
Exploring QSAR. Fundamentals and Applications in Chemistry and Biology, Hansh, C. and Leo, A., Eds., Washington: ACS DC, 1995.
Hansch, C. and Leo, A., Substituent Constants for Correlation Analysis in Chemistry and Biology, New York: Wiley, 1979.
Handbook of Chemistry Property Estimation Methods. Environmental Behavior of Organic Compounds, Lyman, W.J., Reehl, W.J., and Rosenblatt, D.H., Eds., Washington: ACS DC, 1990.
Hansch, C. and Fujita, T., J. Am. Chem. Soc., 1964, vol.86, p. 1616.
Gulyaeva, N., Zaslavsky, A., Lechner, P., Chait, A., and Zaslabsky, B., J. Chromatogr., B, 2000, vol. 743, p. 187.
Cyclobond Handbook, Whippany: Advanced Separation Technologies, 1999.
Davankov, V.A., Zh. Vses. Khim. O-va im. D.I. Mendeleeva, 1989, vol. 34, no. 3, p. 377.
Armstrong, D.W. and Li, W., J. Chromatogr., 1987, p.43.
Anan'eva, I.A., Shapovalova, E.N., Lopatin, S.A., Shpigun, O.A., Varlamov, V.P., and Davankov, V.A., Vestn. Mosk. Univ., Ser. 2: Khim., 2001, vol. 42, no. 4, p. 273.
Chang, S.C., Reid, G.L., Chen, S., Chang, C.D., and Armstrong, D.W., Trends Anal. Chem., 1993, vol. 12, no.4, p. 143.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Anan'eva, I.A., Myshak, E.N., Shapovalova, E.N. et al. Chromatographic Retention and Enantioseparation of Amino Acid Derivatives on Aminated β-Cyclodextrin as Functions of the Hydrophobicity of Adsorbates. Journal of Analytical Chemistry 58, 461–466 (2003). https://doi.org/10.1023/A:1024030231261
Issue Date:
DOI: https://doi.org/10.1023/A:1024030231261