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Antiviral Activity of Some 2'-Deoxyuridine 5-Arylethynyl Derivatives

Russian Journal of Bioorganic Chemistry volume 29, pages 262–266 (2003)Cite this article

Abstract

5-(3-Perylenylethynyl)-2'-deoxyuridine was prepared by crosslinking 5-iodo-2'-deoxyuridine derivatives with 3-ethynylperylene followed by deprotection. 5-(1-Perylenylethynyl)-, 5-(3-perylenylethynyl)-, and 5-[4-(2-benzoxazolyl)phenylethynyl]-2'-deoxyuridine were found to inhibit in Vero cells the replication of type 1 herpes simplex virus and its drug-resistant strains.

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Authors and Affiliations

  1. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, ul. Gamalei 16, Moscow, 123098, Russia

    V. L. Andronova, M. V. Skorobogatyi & G. A. Galegov

  2. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP, Moscow, 117997, Russia

    E. V. Manasova, Yu. A. Berlin & V. A. Korshun

Authors
  1. V. L. Andronova
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  2. M. V. Skorobogatyi
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  3. E. V. Manasova
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  4. Yu. A. Berlin
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  5. V. A. Korshun
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  6. G. A. Galegov
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Correspondence to G. A. Galegov.

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Andronova, V.L., Skorobogatyi, M.V., Manasova, E.V. et al. Antiviral Activity of Some 2'-Deoxyuridine 5-Arylethynyl Derivatives. Russian Journal of Bioorganic Chemistry 29, 262–266 (2003). https://doi.org/10.1023/A:1023936516589

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  • DOI: https://doi.org/10.1023/A:1023936516589

  • antiviral activity
  • HSV-1
  • 5-(3-perylenylethynyl)-2'-deoxyuridine
  • 5-substituted 2'-deoxyuridines
  • type 1 herpes simplex virus