Abstract
Background: The waveform tilt of biphasic shocks yielding the lowest defibrillation threshold (DFT) is not well defined. Some evidence indicates that tilts less than 65% may improve DFTs.
Methods: In 57 patients undergoing ICD implantation, DFTs were determined with truncated exponential biphasic waveform tilts at 65%/65% and at 42%/42%. An external defibrillator with custom software was used for testing. The effective capacitance of the defibrillator was 132-μF for both waveforms. DFTs were determined using a binary search method starting with 12 Joules (J). Patients were randomly assigned to initial testing with either one of the two tilts. Thirty patients (Group 1) were tested with a two electrode (active can to RV coil, or SVC coil to RV coil) and 27 patients (Group 2) were tested with a three electrode system (subcutaneous patch or active can + SVC coil to RV coil).
Results: Groups 1 and 2 did not differ in age, ejection fraction or antiarrhythmic medications. Group 1 delivered energy DFTs were 10.1 ± 5.5 J with the 65%/65% tilt and 10.1 ± 5.9 J for the 42%/42% tilt (p = 0.92). In group 2 the average DFT for the 65%/65% tilt was 8.4 ± 5.7 J and for the 42%/42% tilt was 8.1 ± 5.3 J (p = 0.70). There were no significant differences in DFTs for either group. The system impedance for Group 1 was 64 ± 12 ohms and for Group 2 was 39 ± 6 ohms (p < 0.0001).
Conclusions: We found no differences in DFTs between 65%/65% tilt and 42%/42% tilt using either 2- or 3-electrode defibrillation systems. Further research is needed to optimize waveforms in order to minimize DFTs, which will result in smaller ICDs and/or greater safety margins for defibrillation.
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Shepard, R.K., DeGroot, P.J., Pacifico, A. et al. Prospective Randomized Comparison of 65%/65% Versus 42%/42% Tilt Biphasic Waveform on Defibrillation Thresholds in Humans. J Interv Card Electrophysiol 8, 221–225 (2003). https://doi.org/10.1023/A:1023925423580
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DOI: https://doi.org/10.1023/A:1023925423580