Skip to main content

Advertisement

Log in

Myelopathy from Waldenström's macroglobulinemia: improvement after Rituximab therapy

  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Approximately 20% of patients with Waldenström's macroglobulinemia (WM) have neurological complications; primarily peripheral neuropathies and symptoms related to a hyperviscosity syndrome. We report a rare case of a patient presenting with a slowly progressive myelopathy due to WM who had a marked response to Rituximab therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Dimopoulos MA, Zervas C, Zomas A, Kiamouris C, Viniou NA, Grigoraki V et al.: Treatment ofWaldenstrom's macroglobulinemia with rituximab. J Clin Oncol 20: 2327-2333, 2002

    Google Scholar 

  2. Dimopoulos MA, Panayiotidis P, Moulopoulos LA, Sfikakis P, Dalakas M: Waldenstrom's macroglobulinemia: clinical features, complications, and management. J Clin Oncol 18: 214-226, 2000

    Google Scholar 

  3. Delgado J, Canales MA, Garcia B, Alvarez-Ferreira J, Garcia-Grande A, Hernandez-Navarro F: Radiation therapy and combination of cladribine, cyclophosphamide, and prednisone as treatment of Bing-Neel syndrome: case report and review of the literature. Am J Hematol 69: 127-131, 2002

    Google Scholar 

  4. Torrey JJ, Katakkar SB: Treatable meningeal involvement inWaldenstrom's macroglobulinemia. Ann Intern Med 101: 345-347, 1984

    Google Scholar 

  5. Abad S, Zagdanski AM, Brechignac S, Thioliere B, Brouet JC, Mariette X: Neurolymphomatosis in Waldenstrom's macroglobulinaemia. Br J Haematol 106: 100-103, 1999

    Google Scholar 

  6. Treon SP, Agus DB, Link B, Rodrigues G, Molina A, Lacy MQ et al.: CD20-Directed antibody-mediated immunotherapy induces responses and facilitates hematologic recovery in patients with Waldenstrom's macroglobulinemia. J Immunother 24: 272-279, 2001

    Google Scholar 

  7. Woimant F, Schanen A, Bertail MA, Dupuy M, Lecoz P, Haguenau M et al.: Myelopathy manifesting as macroglobulinemia. Ann Med Interne (Paris) 136: 121-124, 1985

    Google Scholar 

  8. Raizer J, DeAngelis L, Zelenetz A, Abrey L: Activity of Rituximab in primary central nervous system lymphoma (PCNSL). Proc ASCO 19: 166a, 2000

    Google Scholar 

  9. Ruhstaller TW, Amsler U, Cerny T. Rituximab: active treatment of central nervous system involvement by non-Hodgkin's lymphoma? Ann Oncol 11: 374-375, 2000

    Google Scholar 

  10. Harjunpaa A, Wiklund T, Janes R, Collan J, Rosenberg J, Lee D et al.: Complement activation in blood and central nervous system after Rituximab treatment of B-Cell lymphoma. Proc ASCO19: 40a, 2000

    Google Scholar 

  11. Levine TD, Pestronk A: IgM antibody-related polyneuropathies: B-cell depletion chemotherapy using Rituximab. Neurology 52: 1701-1704, 1999

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liberato, B., Riethmuller, A., Comenzo, R.L. et al. Myelopathy from Waldenström's macroglobulinemia: improvement after Rituximab therapy. J Neurooncol 63, 207–211 (2003). https://doi.org/10.1023/A:1023912425610

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1023912425610

Navigation