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Alzheimer' Disease as a Disconnection Syndrome?

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Abstract

This paper reviews the growing amount of evidence supporting the hypothesis that Alzheimer's disease includes a disconnection syndrome. This evidence came mainly from neuropathological, electrophysiological, and neuroimaging studies. Moreover, a few recent neuropsychological studies have also explored the effects of a disconnection between cerebral areas on cognitive functioning. Finally, and more generally, the contribution of this interpretation to the understanding of Alzheimer's disease cognitive deficits is considered.

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Delbeuck, X., Van der Linden, M. & Collette, F. Alzheimer' Disease as a Disconnection Syndrome?. Neuropsychol Rev 13, 79–92 (2003). https://doi.org/10.1023/A:1023832305702

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