Abstract
A search has been made for the conditions of heterocyclization of O-aroyl-β-morpholinopropioamide oximes to 5-aryl-3-(β-morpholino)ethyl-1,2,4-oxadiazoles. We have investigated the heating of the starting compounds above their melting point, at their melting point, and holding in polar solvents (DMSO and DMF). Heating the O-aroylamide oxime hydrochlorides in DMF appeared optimal.
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Kayukova, L.A. Conditions for the Heterocyclization of O-Aroyl-β-morpholinopropioamide Oximes to 5-Aryl-3-(β-morpholino)ethyl-1,2,4-oxadiazoles. Chemistry of Heterocyclic Compounds 39, 223–227 (2003). https://doi.org/10.1023/A:1023724626003
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DOI: https://doi.org/10.1023/A:1023724626003