Abstract
Nucleoside diphosphate (NDP) kinase is required for multiple cellular functions, including cell growth, motility, and differentiation, and its loss is associated with pathologies including tumor metastasis. A recent study has revealed a previously unknown function for NDP kinase as positive regulator of dynamin, a GTPase essential for endocytosis. In this review we describe the evidence that NDP kinase function is essential for endocytosis and also elaborate on a mechanism for NDP kinase regulation of dynamin. Recently documented interactions between endocytosis and cell signaling have revealed new insights into potential mechanisms of cancer. In this context, we discuss the possible relevance of NDP kinase and dynamin interaction for tumor suppression.
Similar content being viewed by others
References
Babst, M., Odorizzi, G., Estepa, E., and Emr, S. (2000). Traffic 1, 248-258.
Baillat, G., Gaillard, S., Castets, F., and Monneron, A. (2002). J. Biol. Chem. 277, 18961-18966.
Biggs J., Hersperger E., Steeg P. S., Liotta L. A., and Shearn A. (1990). Cell 63, 933-940.
Chen, M.-K., Green, D., Liu, L., Lam, Y. C., Mukai, L., Rao, S., Ramagiri, S., Krishnan, K. S., Engel, J. E., Lin, J. J., and Wu, C.-F. (in press). J. Neurosci.
Chen, M. S., Obar, R. A., Schroeder, C. C., Austin, T. W., Poodry, C. A., Wadsworth, S. C., and Vallee, R. B. (1991). Nature 351, 583-586.
de Camilli, P., and Takei, K. (1996). Neuron 16, 481-486.
de Camilli, P., Takei, K., and McPherson, P. S. (1995). Curr. Opin. Neurobiol. 5, 559-565.
Deitcher, D. (2001). Trends Neurosci. 24, 625-626.
Di Fiore, P. P., and de Camilli, P. (2001). Cell 106, 1-4.
Dubois, L., Lecourtois, M., Alexandre, C., Hirst, E., and Vincent, J. P. (2001). Cell 105, 613-624.
Futter, C. E., Pearse, A., Hewlett, L. J., and Hopkins, C. R. (1996). J. Cell. Biol. 132, 1011-1023.
Grant, D., Unadkat, S., Katzen, A., Krishnan, K. S., and Ramaswami, M. (1998). Genetics 149, 1019-1030.
Gruenberg, J., and Maxfield, F. R. (1995). Curr. Opin. Cell. Biol. 7, 552-563.
Hartsough, M. T., and Steeg, P. S. (2000). J. Bioenerg. Biomembr. 32, 301-308.
Herskovits, J. S., Burgess, C. C., Obar, R. A., and Vallee, R. B. (1993). J. Cell. Biol. 122, 565-578.
Kantor, J. D., McCormick, B., Steeg, P. S., and Zetter, B. R. (1993). Cancer Res. 53, 1971-1973.
Kimura, N., and Johnson, G. S. (1983). J. Biol. Chem. 258, 12609-12617.
Kimura, N., Shimada, N., Fukuda, M., Ishijima, Y., Miyazaki, H., Ishii, A., Takagi, Y., and Ishikawa, N. (2000). J. Bioenerg. Biomembr. 32, 309-315.
Kirchhausen, T. (2000). Annu. Rev. Biochem. 69, 699-727.
Koening, J. A., and Edwardson, J. M. (1997). Trends Pharmacol. Sci. 18, 276-287.
Koenig, J. H., and Ikeda, K. (1989). J. Neurosci. 9, 3844-3860.
Kosaka, T., and Ikeda, K. (1983). J. Neurobiol. 14, 207-225.
Kramer, H., Cagan, R. L., and Zipursky, S. L. (1991). Nature 352, 207-212.
Krishnan, K. S., Rikhy, R., Rao, S., Shivalkar, M., Mosko, M., Narayanan, R., Etter, P., Estes, P. S., and Ramaswami, M. (2001). Neuron 30, 197-210.
Leone, A., Flatow, U., King, C. R., Sandeen, M. A., Margulies, I. M., Liotta, L. A., and Steeg, P. S. (1991). Cell 65, 25-35.
Levkowitz, G., Waterman, H., Zamir, E., Kam, Z., Oved, S., Langdon, W. Y., Beguinot, L., Geiger, B., and Yarden, Y. (1998). Genes Dev. 12, 3663-3674.
Lloyd, T. E., Atkinson, R., Wu, M. N., Zhou, Y., Pennetta, G., and Bellen, H. J. (2002). Cell 108, 261-269.
MacDonald, N. J., Freije, J. M., Stracke, M. L., Manrow, R. E., and Steeg, P. S. (1996). J. Biol. Chem. 271, 25107-25116.
Maeda, K., Nakata, T., Noda, Y., Sato-Yoshitake, R., and Hirokawa, N. (1992). Mol. Biol. Cell 3, 1181-1194.
Marks, B., Stowell, M. H., Vallis, Y., Mills, I. G., Gibson, A., Hopkins, C. R., and McMahon, H. T. (2001). Nature 410, 231-235.
Muhlberg, A. B., Warnock, D. E., and Schmid, S. L. (1997). EMBO J. 16, 6676-6683.
Otsuki, Y., Tanaka, M., Yoshii, S., Kawazoe, N., Nakaya, K., and Sugimura, H. (2001). Proc. Natl. Acad. Sci. U.S.A. 98, 4385-4390
Parks, R. E. J., and Agarwal, R. P. (1973). In The Enzymes, Vol. 8 (Boyer, P. D., ed.), Academic Press, New York, pp. 307-333.
Poodry, C. A., and Edgar, L. (1979). J. Cell. Biol. 81, 520-527.
Postel, E. H., Berberich, S. J., Rooney, J. W., and Kaetzel, D. M. (2000). J. Bioenerg. Biomembr. 32, 277-284.
Ramaswami, M., Krishnan, K. S., and Kelly, R. B. (1994). Neuron 13, 363-375.
Robinson, M. S., Watts, C., and Zerial, M. (1996). Cell 84, 13-21.
Rosengard, A. M., Krutzsch, H. C., Shearn, A., Biggs, J. R., Barker, E., Margulies, I. M., King, C. R., Liotta, L. A., and Steeg, P. S. (1989). Nature 342, 177-180.
Salim, K., Bottomley, M. J., Querfurth, E., Zvelebil, M. J., Gout, I., Scaife, R., Margolis, R. L., Gigg, R., Smith, C. I., Driscoll, P. C., Waterfield, M. D., and Panayotou, G. (1996). EMBO J. 15, 6241-6250.
Sever, S., Damke, H., and Schmid, S. L. (2000). Traffic 1, 385-392.
Sever, S., Muhlberg, A. B., and Schmid, S. L. (1999). Nature 398, 481-486.
Shaw, G. (1996). Bioessays 18, 35-46.
Shpetner, H. S., and Vallee, R. B. (1992). Nature 355, 733-735.
Shupliakov, O., Low, P., Grabs, D., Gad, H., Chen, H., David, C., Takei, K., de Camilli, P., and Brodin, L. (1997). Science 276, 259-263.
Takei, K., McPherson, P. S., Schmid, S., and de Camilli, P. (1995). Nature 374, 186-190.
Timmons, L., and Shearn, A. (2000). J. Bioenerg. Biomembr. 32, 293-300.
Tuma, P. L., Stachniak, M. C., and Collins, C. A. (1993). J. Biol. Chem. 268, 17240-17246.
van der Bliek, A., and Meyerowitz, E. (1991). Nature 351, 411-414.
van der Bliek, A. M., Redelmeier, T. E., Damke, H., Tisdale, E. J., Meyerowitz, E. M., and Schmid, S. L. (1993). J. Cell. Biol. 122, 553-563.
Vieira, A. V., Lamaze, C., and Schmid, S. L. (1996). Science 274, 2086-2089.
Wieland, T., and Jakobs, K. H. (1992). Mol. Pharmacol. 42, 731-735.
Xu, J., Liu, L. Z., Deng, X. F., Timmons, L., Hersperger, E., Steeg, P. S., Veron, M., and Shearn, A. (1996). Dev. Biol. 177, 544-557.
Zhu, J., Tseng, Y. H., Kantor, J. D., Rhodes, C. J., Zetter, B. R., Moyers, J. S., and Kahn, C. R. (1999). Proc. Natl. Acad. Sci. U.S.A. 96, 14911-14918.