Abstract
The reaction of ethyl 5-phenylthioureido-3H-imidazole-4-carboxylate with bromoacetic acid afforded (imidazolylimino)thiazolidinones, which were transformed into the corresponding 5-arylidene-4-thiazolidinones by the reactions with aldehydes. Under the conditions of the Knoevenagel reaction, the thiazolidine ring in derivatives of 4-(4-oxothiazolidin-2-ylideneamino)-3H-imidazole-4-carboxamides was opened to form substituted guanidines.
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El"tsov, O.S., Mokrushin, V.S., Bel"skaya, N.P. et al. Synthesis and transformations of (imidazolylimino)thiazolidinones. Russian Chemical Bulletin 52, 461–466 (2003). https://doi.org/10.1023/A:1023439706631
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DOI: https://doi.org/10.1023/A:1023439706631