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Molecular Biology

, Volume 37, Issue 2, pp 205–209 | Cite as

Genetic Peculiarity of the Yakut Population as Inferred from Autosomal Loci

  • I. Yu. Khitrinskaya
  • V. A. Stepanov
  • V. P. Puzyrev
  • M. G. Spiridonova
  • K. V. Puzyrev
  • N. R. Maksimova
  • A. N. Nogovitsyna
Article

Abstract

The autosomal gene pool of Yakuts was analyzed with a panel of polymorphic Alu insertions. The observed allele frequencies were typical for other Asian ethnic groups. Genetic differentiation of three Yakut populations was relatively high, 2%. East Siberian ethnic groups were shown to have a common gene pool and to experience no intense gene flow from other populations. Development of the Yakut gene pool was assumed to involve no substantial genetic effect of neighboring populations. The results fit both autochthonous and southern origin hypotheses.

Alu repeat genetic polymorphism ethnogenetics 

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REFERENCES

  1. 1.
    Cavalli-Sforza L.L., Menozzi P., Piazza A. 1994. The history and geography of human genes. Princeton: Prinseton Univ. Press.Google Scholar
  2. 2.
    Genofond i genogeografiya narodonaseleniya (Human Gene Diversity and Gene Geography). St. Petersburg: Nauka. 2000. vol. 1.Google Scholar
  3. 3.
    Wallace D.C. 1995. Mitochondrial DNA variation in human evolution, degenerative disease and aging. Am. J. Hum. Genet. 57, 201–223.Google Scholar
  4. 4.
    Jorde L.B., Bamshad M., Rogers A.R. 1998. Using mitochondrial and nuclear DNA markers to reconstruct human evolution. BioEssays. 20, 126–136.Google Scholar
  5. 5.
    Stoneking M., Fontius J.J., Clifford S.L., Soodyall H. et al. 1997. Alu insertion polymorphism and human evolution: evidence for a larger population size in Africa. Genome Res. 7, 1061–1071.Google Scholar
  6. 6.
    Bowcock A.M., Ruiz-Linares A., Tomfohrde J. et al. 1994. High resolution of human evolutionary trees with polymorphic microsatellites. Nature. 386, 455–457.Google Scholar
  7. 7.
    Narody Rossii: entsiklopediya (Ethnic Groups of Russia: An Encyclopedia). 1994. Tishkov V.A., Ed. Moscow: Bol'shaya Rossiiskaya Entsiklopediya.Google Scholar
  8. 8.
    Gogolev A.I. 2000. Istoriya Yakutii (Obzor istoricheskikh sobytii do nachala XX veka) (History of Yakutia (A review of historical events up to the early 20th century)). Yakutsk: Yakutsk. Univ.Google Scholar
  9. 9.
    Tishkoff S.A., Dietzsch E., Speed W. et al. 1996. Global patterns of linkage equilibrium at the CD4 lokus and modern human origins. Science. 271, 1380–1387.Google Scholar
  10. 10.
    Majumder P.P., Roy B., Banrjee S. et al. 1999. Humanspecific insertion/deletion polymorphisms in Indian populations and their possible evolutionary implications. Eur. J. Hum. Genet. 7, 435–446.Google Scholar
  11. 11.
    Stepanov V.A., Puzyrev V.P., Spiridonova M.G., Khitrinskaya I.Yu. 1999. Analysis of Alu polymorphisms in urban and rural Russian populations of Siberia. Genetika. 35, 1138–1143.Google Scholar
  12. 12.
    Stepanov V.A., Khitrinskaya I.Yu., Puzyrev V.P. 2000. Genetic differentiation of the Siberian indigenous population, as revealed by Alu polymorphisms. Genetika cheloveka i patologiya (Human Genetics and Pathology). Puzyrev V.P., Ed. Tomsk: STT. 5, 98–107.Google Scholar
  13. 13.
    Stepanov V.A., Khitrinskaya I.Yu., Puzyrev V.P. 2001. Genetic differentiation of the Tuva population with respect to the Alu insertions. Genetika. 37, 563–569.Google Scholar
  14. 14.
    Stepanov V.A., Puzyrev V.P., Spiridonova M.G., Kharkov V.N., Soltobaeva J.O. 2002. Y-chromosome diversity in population of Altaic language family. in Thesis of HUGO Meeting. Edinburgh.Google Scholar
  15. 15.
    Khitrinskaya I.Yu., Stepanov V.A., Puzyrev V.P. 2001. Analysis of Alu polymorphisms in Buryat populations. Genetika. 37, 1553–1558.Google Scholar
  16. 16.
    Novick G.E., Batzer M.A., Deininger P.L., Herrera R.J. 1996. The mobile genetic element Alu in the human genome. Bioscience. 46, 32–41.Google Scholar
  17. 17.
    Batzer M.A., Deininger P.L. 2002. Alu repeats and human genomic diversity. Nature Rev. Genetics. 3, 370–379.Google Scholar
  18. 18.
    Batzer M.A., Arcot S.S., Phinney J.M. et al. 1996. Genetic variation of recent Alu-insertions in human populations. J. Mol. Evol. 42, 22–29.Google Scholar
  19. 19.
    Arcot S.S., Fontius J.J., Deininger P.L., Batzer M.A. 1995. Identification and analysis of a “young” polymorphic Alu element. Biochim. Biophys. Acta. 1263, 99–102.Google Scholar
  20. 20.
    Zhivotovsky L.A. 1991. Populyatsionnaya biometriya (Population Biometrics). Moscow: Nauka.Google Scholar
  21. 21.
    Nei M. 1987. Molecular evolutionary genetics. N.Y.: Columbia Univ. Press.Google Scholar
  22. 22.
    Saitou N., Nei M. 1987. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol. Biol. Evol. 4, 406–425.Google Scholar
  23. 23.
    Felsenstein J. 1993. PHYLIP, version 3.5. Univ. of Washington, Seattle.Google Scholar
  24. 24.
    Harpending H.C., Ward R.H. 1982. Chemical systematics and human populations. in: Biochemical Aspects of Evolutionary Biology. Nitecki M.H. Ed. Chicago: Univ. of Chicago Press.Google Scholar
  25. 25.
    Dubrova E.Yu., Bogatyreva L.V., Pushkina E.I. 1992. Variation of polymorphic gene markers in Buryat and Russian newborns of Ulan-Ude. Genetika. 28, 153–158.Google Scholar
  26. 26.
    Wright S. 1943. Isolation by distance. Genetics. 28, 139–156.Google Scholar
  27. 27.
    Wright S. 1951. The genetical structure of populations. Ann. Eugenics. 15, 323–354.Google Scholar

Copyright information

© MAIK “Nauka/Interperiodica” 2003

Authors and Affiliations

  • I. Yu. Khitrinskaya
    • 1
  • V. A. Stepanov
    • 1
  • V. P. Puzyrev
    • 1
    • 2
  • M. G. Spiridonova
    • 1
  • K. V. Puzyrev
    • 3
  • N. R. Maksimova
    • 4
  • A. N. Nogovitsyna
    • 4
  1. 1.Institute of Medical Genetics, Tomsk Research CenterRussian Academy of Medical SciencesTomskRussia
  2. 2.Siberian Medical UniversityTomskRussia
  3. 3.Institute of Cardiology, Tomsk Research CenterRussian Academy of Medical SciencesTomskRussia
  4. 4.Republican Hospital no. 1, National Center of MedicineMinistry of Health of the Sakha Republic (Yakutia)YakutskRussia

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