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Relationship between the structure of different phosphonates and the preparation of corresponding complexes labeled with 153Sm

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Abstract

Structure activity relationship (SAR) has been playing a more and more important role in medicine design. We presented here a preliminary investigation on the relationship between the structure of different phosphonates and the preparation of corresponding complexes labeled with 153Sm. By study of seven complexes, it was found that the number of -PO3H2 groups, the stereoscopic distance between them and the existence of strong electron-providing groups in the ligand molecule affected the preparation of 153Sm-complex.

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Authors and Affiliations

  1. Institute of Nuclear Physics and Chemistry, Chinese Academy of Engineering Physics, P.O. Box 919-230, Mianyang , Sichuan, 621900, P. R. China

    Y. Q. Yang, Sh. Zh. Luo, M. F. Pu, J. H. He, W. Z. Bing & G. Q. Wang

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  1. Y. Q. Yang
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  2. Sh. Zh. Luo
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  3. M. F. Pu
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  4. J. H. He
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  5. W. Z. Bing
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  6. G. Q. Wang
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Yang, Y.Q., Luo, S.Z., Pu, M.F. et al. Relationship between the structure of different phosphonates and the preparation of corresponding complexes labeled with 153Sm. Journal of Radioanalytical and Nuclear Chemistry 256, 133–136 (2003). https://doi.org/10.1023/A:1023368529896

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  • DOI: https://doi.org/10.1023/A:1023368529896

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