Skip to main content

Advertisement

Log in

Metaplastic bone formation in a low grade conus glioma: case report and review of the literature

  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Calcifications associated with both benign and neoplastic intra-axial lesions of the central nervous system (CNS) are well recognized. Bony metaplasia in the CNS, where there is formation of mature trabecular bone, is a much more rare entity and has not been reported in the spinal cord. We present a case of bony metaplasia in the conus medullaris associated with a low grade astrocytoma. Radiological, pathological and clinical features of this unique case are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Cardozo J, Cepeda F, Quintero M, Mora E: Choroid plexus papilloma containing bone. Acta Neuropathol (Berl) 68: 83–85, 1985

    Google Scholar 

  2. Demaerel P, Casaer P, van Calenbergh F, Knapen P, Wilms G, Plets C, Baert A: Iatrogenic spinal epidermoid tumour associated with tuberous sclerosis. A diagnostic pitfall. J Neuroradiol 21: 270–273, 1994

    Google Scholar 

  3. Doita M, Harada T, Nishida K, Marui T, Kurosaka M, Yoshiya S: Recurrent calcified spinal meningioma detected by plain radiograph. Spine 26: E249–E252, 2001

    Google Scholar 

  4. Duckett S, Osterholm J, Schaefer D, Gonzales C, Schwartzman RJ: Ossified mucin-secreting choroid plexus adenoma: case report. Neurosurgery 29: 130–132, 1991

    Google Scholar 

  5. Kawamata T, Kubo O, Kawamura H, Iwata Y, Kagawa M, Kitamura K: Ossified choroid plexus papilloma - case report. No Shinkei Geka 16: 989–994, 1988

    Google Scholar 

  6. Kim KM: Apoptosis and calcification. Scanning Microsc 9: 1137–1175, 1995; discussion 1175-1178

    Google Scholar 

  7. Knupfer M, Rieske K, Pulzer F, Trantakis C, Dietrich J, Handrick W: Incipient spinal cord compression syndrome due to a herniation of calcified intervertebral disk in a young girl. Klin Paediatr 212: 117–120, 2000

    Google Scholar 

  8. Kubota T, Kogure Y, Yamamoto S, Matsubara S, Kitano T, Hayashi M: Calcification in glioblastoma multiforme of the cervical spinal cord. Surg Neurol 26: 183–186, 1986

    Google Scholar 

  9. Leweke F, Christophis P, Kern A, Schachenmayr W: Metaplastic ossification in an acoustic neurinoma. Zentralbl Neurochir 58: 183–186, 1997

    Google Scholar 

  10. Marquis JR, Lee JK: Extensive central nervous system calcification in a stillborn male infant due to cytomegalovirus infection. Am J Roentgenol 127: 665–667, 1976

    Google Scholar 

  11. Mathews T, Moossy J: Gliomas containing bone and cartilage. J Neuropathol Exp Neurol 33: 456–471, 1974

    Google Scholar 

  12. Ming-Tak DH, Hs CY, Wong TT, Chian H: A clinicopathologic study of 81 patients with ependymomas and proposal of diagnostic criteria for anaplastic ependymoma. J Neuro-Oncol 54: 77–85, 2001

    Google Scholar 

  13. Naim-Ur-Rahman, Jamjoom A, al-Rayess M: Intramedullary ossified cavernous angioma of the spinal cord: case report. Br J Neurosurg 12: 267–270, 1998

    Google Scholar 

  14. Nakamura Y, Sato T, Nishimura G, Tanimura A, Takahashi Y, Hachisuka H, Masaike K, Yanai T, Hashimoto H: Malignant teratoma in the brain. An immunohistochemical study. Cancer 55: 103–107, 1985

    Google Scholar 

  15. Roncaroli F, Fioravanti A, Marliani AF, Calbucci F: Osseous metaplasia in a growth hormone-secreting pituitary adenoma. Clin Neuropathol 18: 205–207, 1999

    Google Scholar 

  16. Seifert G: Heterotopic (extraosseous) calcification (calcinosis). Etiology, pathogenesis and clinical importance] Pathologe 18: 430–438, 1997

    Google Scholar 

  17. Shikata J, Yamamuro T, Iida H, Kashiwagi N: Calcification of spinal cord tumors: report of two cases. Nippon Geka Hokan 58: 140–146, 1989

    Google Scholar 

  18. Tanaka T, Shimoyama I, Endoh M, Hinokuma K, Ninchoji T, Uemura K, Nakamura S, Kinou I, Kitanaka H, Kondo A: Thoracolumbar spinal cord astrocytoma with intense calcifi-cation. Case report. Neurol Med Chir (Tokyo) 26: 728–733, 1986

    Google Scholar 

  19. Tsurushima H, Kamezaki T, Noguti S, Yoshii Y, Nose T: Subependymal tumor with metaplastic bone formation: a case report. No Shinkei Geka 25: 949–952, 1997

    Google Scholar 

  20. Walsh E, Cramer B, Shah S: Spinal cord calcification in congenital cytomegalovirus infection. AJR Am J Roentgenol 155: 1142–1143, 1990

    Google Scholar 

  21. Waubant E, Manelfe C, Bonafe A, Berry I, Clanet M: MRI of intramedullary sarcoidosis: follow-up of a case. Neuroradiology 39: 357–360, 1997

    Google Scholar 

  22. Willinsky R, Tator C, Lewis A, Cooper P, Kassel E: Epidermoid tumor: an unusual cause of ossification within the spinal canal. Can Assoc Radiol J 37: 56–59, 1986

    Google Scholar 

  23. Yamamoto Y, Tsuji T, Suga M, Sunami N, Yamamoto Y, Kunishio K, Sonobe H: Diffuse cerebrospinal gliomatosis. Case report Neurol Med Chir (Tokyo) 31: 1023–1029, 1991

    Google Scholar 

  24. Yanagawa Y, Miyazawa T, Ishihara S, Takiguchi H, Shima K, Terahata S, Tamai S, Chigasaki H: Pontine glioma with osteoblastic skeletal metastases in a child. Surg Neurol 46: 481–484, 1996

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Siomin, V., Willinsky, R., Shannon, P. et al. Metaplastic bone formation in a low grade conus glioma: case report and review of the literature. J Neurooncol 62, 275–280 (2003). https://doi.org/10.1023/A:1023366405828

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1023366405828

Navigation