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Feasibility of isotopic exchange in the system [125I] iodide - undecahydro-iodo-closo-dodecaborate(2-) anion

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Abstract

Derivatives of the closo-dodecaborate dianion are routinely used or proposed for use in boron neutron capture therapy of cancer. The use of radioactive label on closo-dodecaborate might facilitate pharmacokinetic studies. The use of nucleophilic reactions might be of advantage if derivatives of closo-dodecaborate were oxidation sensitive. The aim of this study was to estimate the feasibility of isotopic exchange in radioiodide - iodo-undecahydro-closo-dodecaborate system. We demonstrated that copper-catalyzed isotope exchange in this system in molten acetamide provides a labeling yield of 78.4±1.1% after 30 minutes at 170 °C. The influence of the ratio between amounts of substrate and catalyst, temperature and time on the labeling yield was studied.

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Authors and Affiliations

  1. Central Research Institute of Roentgenology and Radiology, St. Petersburg, Russia

    M. V. Korsakov, E. V. Shchukin & L. N. Korsakova

  2. Division of Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

    A. M. Orlova

  3. Department of Organic Chemistry, Uppsala University, Uppsala, Sweden

    S. Sjöberg & V. Tolmachev

Authors
  1. M. V. Korsakov
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  2. E. V. Shchukin
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  3. L. N. Korsakova
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  4. A. M. Orlova
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  5. S. Sjöberg
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  6. V. Tolmachev
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Korsakov, M.V., Shchukin, E.V., Korsakova, L.N. et al. Feasibility of isotopic exchange in the system [125I] iodide - undecahydro-iodo-closo-dodecaborate(2-) anion. Journal of Radioanalytical and Nuclear Chemistry 256, 67–71 (2003). https://doi.org/10.1023/A:1023348025353

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  • DOI: https://doi.org/10.1023/A:1023348025353

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