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Generation of CD8+ Cytotoxic T Lymphocytes Against Breast Cancer Cells by Stimulation with Mammaglobin-A-Pulsed Dendritic Cells

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Abstract

Mammaglobin-A is exclusively expressed by breast cancer cells. Thus, mammaglobin-A-specific T cell immune responses may be useful for the design of new breast cancer-specific immunotherapies. We show herein that CD8+ T cells generated against recombinant mammaglobin-A-pulsed dendritic cells display a marked cytotoxic activity against mammaglobin-A-positive breast cancer cell lines. This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer.

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Authors and Affiliations

  1. Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA

    Partha P. Manna, Andrés Jaramillo, Kanchana Majumder, Lacey G. Campbell, Timothy P. Fleming & T. Mohanakumar

  2. Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

    Jill R. Dietz & John F. Dipersio

  3. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

    T. Mohanakumar

Authors
  1. Partha P. Manna
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  2. Andrés Jaramillo
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  3. Kanchana Majumder
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  4. Lacey G. Campbell
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  5. Timothy P. Fleming
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  6. Jill R. Dietz
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  7. John F. Dipersio
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  8. T. Mohanakumar
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Manna, P.P., Jaramillo, A., Majumder, K. et al. Generation of CD8+ Cytotoxic T Lymphocytes Against Breast Cancer Cells by Stimulation with Mammaglobin-A-Pulsed Dendritic Cells. Breast Cancer Res Treat 79, 133–136 (2003). https://doi.org/10.1023/A:1023323509888

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  • DOI: https://doi.org/10.1023/A:1023323509888

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