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Aldosterone Binding by Compensatory Hypertrophied Kidney with Disturbed Neurotrophic Supply in Rats

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Abstract

We studied certain aspects of interaction between (3H)aldosterone and the cytoplasmic as well as nuclear receptors of renal cells in the rats during compensatory renal hypertrophy at the background of reflex renal dystrophy. The dystrophy developing in the kidney after cutting the sciatic nerve blocks the compensatory increase in specific accumulation of (3H)aldosterone in the cytoplasm of the renal tubular cells. (3H)Aldosterone transport from the cytoplasmic receptors to the nuclear receptors during rat reflex dystrophy of compensatory hypertrophied kidney is lower as compared to the control. The reflex dystrophy induced by a sciatic nerve injury proved to have no effect on the degree of hypertrophy of the only kidney.

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Authors and Affiliations

  1. Russian Academy of Sciences, Institute of Higher Nervous Activity and Neurophysiology, ul. Butlerova 5a, Moscow, 117485, Russia

    Yu. A. Akimov & N. S. Kositsyn

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  1. Yu. A. Akimov
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  2. N. S. Kositsyn
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Akimov, Y.A., Kositsyn, N.S. Aldosterone Binding by Compensatory Hypertrophied Kidney with Disturbed Neurotrophic Supply in Rats. Biology Bulletin 30, 160–163 (2003). https://doi.org/10.1023/A:1023293323179

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