Abstract
New derivatives of bacteriochlorophyll a bearing an extra glutarimide exocycle were synthesized, and their reactivity was studied. Acetyl group in 3-acetyl-2,7,12,18-tetramethyl-8-ethyl-13,15-dicarboxy-17-carboxyethyl-7,8,17,18-tetrahydroporphyrin (bacteriochlorin p) was chemically modified into α-hydroxyethyl and vinyl groups. A simple method of preparation of vinylbacteriopurpurin esters under the catalysis by p-toluenesulfonic acid was proposed. The resulting compounds exhibit a high adsorption in the visible and near IR areas of electronic spectra, a reasonable stability, and amphiphilic properties and, therefore, may be regarded as promising photosensitizers for the photodynamic cancer therapy.
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Mironov, A.F., Grin, M.A., Tsiprovskii, A.G. et al. New Photosensitizers of Bacteriochlorin Series for Photodynamic Cancer Therapy. Russian Journal of Bioorganic Chemistry 29, 190–197 (2003). https://doi.org/10.1023/A:1023272718636
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DOI: https://doi.org/10.1023/A:1023272718636