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Synthesis of Derivatives of 2-(Indol-1-yl)propionic Acids

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

We have developed a method for synthesis of N-substituted derivatives of indole from N-phenylalanine, including Fischer cyclization of the corresponding arylalkylhydrazones. The starting hydrazines were obtained by reduction of the corresponding nitrosamines. We have established that the optimum reduction method is to use metallic zinc in a methanol-hydrochloric acid system at low temperatures.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, Moscow, 119234, Russia

    A. V. Kurkin, N. E. Golantsov, A. V. Karchava & M. A. Yurovskaya

Authors
  1. A. V. Kurkin
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  2. N. E. Golantsov
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  3. A. V. Karchava
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  4. M. A. Yurovskaya
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Kurkin, A.V., Golantsov, N.E., Karchava, A.V. et al. Synthesis of Derivatives of 2-(Indol-1-yl)propionic Acids. Chemistry of Heterocyclic Compounds 39, 74–82 (2003). https://doi.org/10.1023/A:1023072709260

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  • DOI: https://doi.org/10.1023/A:1023072709260

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