Abstract
The solubility enhancement of triflumizole by complexation with β-cyclodextrin and with dimethyl-β-cyclodextrin is compared with respect to the different physico-chemical properties of the host molecules. Although the inclusion reaction constants are rather similar for both complexation reactions, a completely different temperature dependence of the host-guest interaction is observed, which indicates a change of the reaction mechanisms. Moreover, the influence of ethanol as cosolvent is studied.
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Viernstein, H., Weiss-Greiler, P. & Wolschann, P. Solubility Enhancement of Low Soluble Biologically Active Compounds by β-Cyclodextrin and Dimethyl-β-cyclodextrin. Journal of Inclusion Phenomena 44, 235–240 (2002). https://doi.org/10.1023/A:1023050501551
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DOI: https://doi.org/10.1023/A:1023050501551