Abstract
The analgesia effects of intrathecal adenosine A1 receptor agonist, R-PIA, on the hyperalgesia and CSF-glutamate release after formalin injection into the rat paw were evaluated. R-PIA significantly and dose-dependently attenuated increases in flinching behavior, and this attenuating effect was reversed by the adenosine A1 receptor antagonist, aminophylline. Morphine blocked flinchs, however MK-801 partially abolished. The increase in CSF-glutamate release evoked by formalin stimulation was inhibited by morphine but not by either R-PIA or MK-801. These findings suggest that the intrathecal adenosine A1 receptor agonist provokes analgesic effect via the postsynaptic action independent of an effect upon spinal glutamate release.
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Yamamoto, S., Nakanishi, O., Matsui, T. et al. Intrathecal Adenosine A1 Receptor Agonist Attenuates Hyperalgesia Without Inhibiting Spinal Glutamate Release in the Rat. Cell Mol Neurobiol 23, 175–185 (2003). https://doi.org/10.1023/A:1022997805525
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DOI: https://doi.org/10.1023/A:1022997805525