Investigational New Drugs

, Volume 21, Issue 1, pp 109–111 | Cite as

Phase II Study of Single Agent Paclitaxel in Adult Patients with Relapsed Acute Lymphocytic Leukemia

  • Dawn E. Colburn
  • Deborah A. Thomas
  • Francis J. Giles


Background: A phase II study of paclitaxel in patients with relapsed adult acute lymphocytic leukemia (ALL) was conducted. Methods: Patients with relapsed ALL, no more than one prior salvage regimen, and no overt hepatic, renal, or cardiac dysfunction were eligible. Patients received paclitaxel 250 mg/m2 given as a continuous 24 -h intravenous infusion repeated every 3–4 weeks. Results: Eight patients received 13 courses of paclitaxel. One transient partial response was observed. The only severe extramedullary toxicities observed were Grade 3 myalgias and arthralgias. Conclusion: The study paclitaxel regimen was ineffective in refractory adult ALL.

paclitaxel refractory acute lymphocytic leukemia adult 


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Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Dawn E. Colburn
    • 1
  • Deborah A. Thomas
    • 1
  • Francis J. Giles
    • 1
  1. 1.Department of LeukemiaThe University of Texas, M.D. Anderson Cancer CenterHoustonUSA

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