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LPO and Ethanol Biotransformation Systems in the Liver as Markers of Predisposition to Ethanol Hepatotoxicity

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Abstract

An original experimental model for detecting organ-specific markers of predisposition to ethanol hepatotoxicity is proposed. A relationship between congenital activity of LPO processes in rat liver (before ethanol intoxication) and the type and severity of ethanol-induced damage to the liver was demonstrated using methods of mathematical modeling. It was proven that intact rats with genetically high MDA levels in the liver and more active systems of MDA generation in ascorbate- and NADPH-dependent reactions are prone to ethanol-induced damage to the liver.

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REFERENCES

  1. G. Z. Abakumov, G. K. Novitskii, and L. F. Legon'kova, Vopr. Med. Khim., No. 6, 30–32 (1988).

  2. A. Afifi and S. Eizen, Statistical Analysis. Computer-Aided Approach [in Russian], Moscow (1982).

  3. V. G. Kolb and V. S. Kamyshnikov, Handbook of Clinical Chemistry [in Russian], Minsk (1982), pp. 111–121.

  4. V. Yu. Urback, Statistical Analysis in Biological and Medical Studies [in Russian], Moscow (1975).

  5. N. Frunder, Vopr. Med. Khim., 14,No. 2, 130–136 (1968).

    Google Scholar 

  6. S. Sherlock and J. Dooley, Diseases of the Liver and Bile Ducts [in Russian], Moscow (1999), pp. 440–462.

  7. J. A. Buege and S. D. Aust, Methods Enzymol., 52, 306–312 (1978).

    Google Scholar 

  8. T. Castillo, D. R. Koop, and S. Kannimura, Hepatology, 16, 992 (1992).

    Google Scholar 

  9. J. C. Fernandez-Checa, C. Garcia-Ruiz, and M. Ookhtens, J. Clin. Invest., 87, 397–404 (1991).

    Google Scholar 

  10. G. M. Higgins and R. M. Anderson, Arch. Pathol., 12,No. 2, 186–202 (1931).

    Google Scholar 

  11. Ch. S. Lieber and L. De Carli, J. Hepatol., 12, 394–401 (1991).

    Google Scholar 

  12. J. P. Persijn and W. Van der Slik, J. Clin. Chem. Biochem., 14, 421–427 (1976).

    Google Scholar 

  13. R. O. Reoknagel and A. K. Ghoshal, Nature, 210, 1126–1163 (1966).

    Google Scholar 

  14. R. D. Situnayake, B. J. Crump, and D. I. Thumham, Gut, 31, 1311–1319 (1990).

    Google Scholar 

  15. S. O. Tottmar, H. Petterson, K. H. Kiessling, Biochem. J., 135, 577–586 (1973).

    Google Scholar 

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Authors and Affiliations

  1. Medical University, Ministry of Health of Belarus' Republic, Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno

    M. I. Bushma, Yu. G. Ambrushkevich, S. M. Zimatkin, K. M. Bushma, S. N. Omel'yanchik, V. S. Slyshenkov, N. G. Mel'nichenko, A. B. Kuz'mich & M. A. El'chaninova

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  1. M. I. Bushma
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  2. Yu. G. Ambrushkevich
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  3. S. M. Zimatkin
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  4. K. M. Bushma
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  5. S. N. Omel'yanchik
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  6. V. S. Slyshenkov
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  7. N. G. Mel'nichenko
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  8. A. B. Kuz'mich
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  9. M. A. El'chaninova
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Bushma, M.I., Ambrushkevich, Y.G., Zimatkin, S.M. et al. LPO and Ethanol Biotransformation Systems in the Liver as Markers of Predisposition to Ethanol Hepatotoxicity. Bulletin of Experimental Biology and Medicine 134, 600–604 (2002). https://doi.org/10.1023/A:1022981616605

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  • DOI: https://doi.org/10.1023/A:1022981616605

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