Abstract
Prostate cancer is the second leading cause of cancer-related death among American men. Biopsy for prostate cancer is a procedure known as transrectal ultrasound-guided needle biopsy. Because of the low resolution of ultrasound, the urologist cannot usually distinguish between cancerous and healthy tissue. For this reason, most biopsies follow standard protocols based on long-term experience of physicians. Recent studies indicate that these protocols have a significant rate of false negative diagnoses. In this research we use real prostate specimens removed by prostatectomy to develop a 3-D distribution map of cancer in the prostate, and use this to develop optimized biopsy procedures. The new procedures have detection rates that are significantly higher than those of current procedures, and thus have the potential to increase the rate of early detection of prostate cancer.
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References
American Cancer Society web page, http://www.cancer.org/statistics/.
C. Bankhead, Sextant biopsy helps in prognosis of Pca, but its not foolproof, Urology Times 25(8) (1997).
J.J. Bauer, J. Zeng, J. Weir,W. Zhang, I.A. Sesterhenn, R.R. Connelly, S.K. Mun and J. Moul, Threedimensional computer-simulated prostate models: lateral prostate biopsies increase the detection rate of prostate cancer, Urology 53 (1999) 961–967.
J.J. Chang, K. Shinohara, V. Bhargava, J.C. Presti, Jr., Prospective evaluation of lateral biopsies of the peripheral zone for prostate cancer detection, J. Urology 160 (1997) 2111–2114.
A.L. Eskew, R.L. Bare and D.L. McCullough, Systematic 5-region prostate biopsy is superior to sextant method for detecting carcinoma of the prostate, J. Urology 157 (1997) 199–202.
C.A. Floudas, Nonlinear and Mixed-Integer Optimization (Oxford University Press, Oxford, 1995).
A.M Geoffrion, Generalized Bender's decomposition, J. Optim. Theory Appl. 10 (1972) 237–253.
K.K. Hodge, J.E. McNeal, M.K. Terris and T.A. Stamey, Random systematic versus directed ultrasound guided trans-rectal core biopsies of the prostate, J. Urology 142 (1989) 71–74.
W. Lin, C. Liang and C. Cheng, Dynamic elastic interpolation for 3D medical inage reconstruction from serial cross section, IEEE Trans. Medical Imaging 7 (1988) 225–232.
G.J. O'Dowd, M.C. Miller, R. Orozco and R.W. Veltri, Analysis of repeated biopsy results within 1 year after a noncancer diagnosis, Urology 55(4) (2000) 553–558.
F. Rabbani, N. Stroumbakis, B.R. Kava, M.S. Cookson and W.R. Fair, Incidence and clinical signifi-cance of false-negative sextant prostate biopsies, J. Urology 159 (1998) 1247–1250.
M.K. Terris, Extended field prostate biopsies: Too much of a good thing?, Urology 55(4) (2000) 457–460.
J. Xuan, I. Sesterhenn, W.S. Hayes, Y. Wang, T. Adali, Y. Yagi, M.T. Freedman and S.K. Mun, Surface reconstruction and visualization of the surgical prostate model, Proc. of SPIE Medical Imaging Conference 3031 (1997) 50–61.
J. Zeng, J.J. Bauer, X. Yao,W. Zhang, I.A. Sesterhenn, R.R. Connelly, J. Moul and S.K. Mun, Building an accurate 3D map of prostate cancer using computerized models of 280 whole-mounted radical prostatectomy specimens, Proc. of SPIE Medical Imaging Conference 3976 (2000) 466–477.
J. Zeng, C. Kaplan, J.J. Bauer, I. Sesterhenn, J. Moul and S.K. Mun, Visualization and evaluation of prostate needle biopsy, in: Proc. of the First International Conference on Medical Image Computing and Computer-Assisted Intervention (1998).
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Sofer, A., Zeng, J. & Mun, S.K. Optimal Biopsy Protocols for Prostate Cancer. Annals of Operations Research 119, 63–74 (2003). https://doi.org/10.1023/A:1022974221137
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DOI: https://doi.org/10.1023/A:1022974221137