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Effect of Epidural Infusion of Isobaric 2% Lidocaine on Spinal Cord Ganglionic Neurons

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Abstract

We analyzed morphological and histoenzymologic changes in spinal cord ganglionic neurons of mongrel dogs caused by epidural infusion of isobaric 2% lidocaine. Lidocaine produced no pathological structural and metabolic alterations in the nervous tissue. Both epidural infusion of 0.9% NaCl and lidocaine produced some morphofunctional rearrangements in spinal ganglionic neurons. These alterations were within the limits of physiological norm and probably attested to functional response of the examined nerve tissue structures to epidural infusion.

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Authors and Affiliations

  1. Department of Anesthesiology and Reanimatology, Department of Pathomorphology, Department of Pharmacology and Clinical Pharmacology, I. P. Pavlov State Medical University, St. Petersburg

    V. A. Volchkov, N. V. Boikova, A. A. Zaitsev, V. I. Strashnov & V. V. Tomson

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  1. V. A. Volchkov
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  2. N. V. Boikova
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  3. A. A. Zaitsev
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  4. V. I. Strashnov
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  5. V. V. Tomson
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Volchkov, V.A., Boikova, N.V., Zaitsev, A.A. et al. Effect of Epidural Infusion of Isobaric 2% Lidocaine on Spinal Cord Ganglionic Neurons. Bulletin of Experimental Biology and Medicine 134, 583–587 (2002). https://doi.org/10.1023/A:1022973414788

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