Skip to main content
SpringerLink
Log in

Erysod, Erythrocyte Superoxide Dismutase Preparation: Effects on LPO Processes and Morphological Changes in the Viscera of Rats with Burns under Conditions of Delayed Antishock Infusion Therapy

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Biochemical and morphological changes in the kidneys, liver, heart, and lungs were studied in rats with deep burns of 20% body surface. Erysod (0.47 mg/kg/day) added to antishock therapy notably reduced the intensity of LPO processes in tissues both in cases when infusion therapy was started immediately (by 8-20% 12 h and by 5-24% 24 h after the injury) and when this therapy was 6 h delayed (by up about 36% after 12 h). This prevented injuries to visceral organs during the acute period of thermal injury and prevented the development of burn disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. V. G. Gavrilov, A. R. Gavrilova, and L. M. Mazhul', Vopr. Med. Khim., 33, 118–122 (1987).

    Google Scholar 

  2. N. I. Kochetygov, On Experimental Reproduction of Thermal Burns [in Russian], Leningrad (1964).

  3. E. I. L'vovskaya, Disorders in Lipid Peroxidation Processes in Thermal Injury and Pathogenetic Validation of Therapy with Plasma Antioxidants, Abstract of Doct. Med. Sci. Dissertation, Moscow (1998).

  4. E. B. Men'shikov and N. K. Zenkov, Uspekhi Sovrem. Biol., 113, 442–455 (1993).

    Google Scholar 

  5. V. Rudovskii, V. Nazilovskii, V. Zitkevich, and K. Zinkevich, Theory and Practical Treatment of Burns [in Russian], Moscow (1980).

  6. S. Kawai, J. Komura, Y. Asada, and Y. Niwa, Arch. Dermatol. Res., 280, 171–175 (1988).

    Google Scholar 

  7. D. Konukoglu, O. Cetinkale, and R. Bulan, Burns, 23, 541–544 (1997).

    Google Scholar 

  8. D. Saitoh, Y. Okada, T. Takahara, et al., J. Exp. Med., 174, 31–40 (1994).

    Google Scholar 

  9. M. Sakurai, H. Tanaka, T. Matsuda, et al., J. Surg. Res., 73, 24–27 (1997).

    Google Scholar 

  10. H. Tanaka, H. Matsuda, S. Shimazaki, et al., Arch. Surg., 132, 158–161 (1997).

    Google Scholar 

  11. Z. F. Xia, R. E. Barrow, L. D. Broemeling, and D. N. Herndon, J. Burn Care Rehabil., 13, 530–537 (1992).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. St. Petersburg-Tekhnologiya Company, St. Petersburg

    B. A. Paramonov, I. V. Churilova, E. V. Zinov'ev & V. Yu. Chebotarev

Authors
  1. B. A. Paramonov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. V. Churilova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. V. Zinov'ev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. Yu. Chebotarev
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Paramonov, B.A., Churilova, I.V., Zinov'ev, E.V. et al. Erysod, Erythrocyte Superoxide Dismutase Preparation: Effects on LPO Processes and Morphological Changes in the Viscera of Rats with Burns under Conditions of Delayed Antishock Infusion Therapy. Bulletin of Experimental Biology and Medicine 134, 578–582 (2002). https://doi.org/10.1023/A:1022921430717

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1022921430717

Search

Navigation