Skip to main content
SpringerLink
Log in

Effect of Vilon and Epithalon on Activity of Enzymes in Epithelial and Subepithelial Layers in Small Intestine of Old Rats

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Per os administration of Vilon (Lys-Glu) or Epithalon (Ala-Glu-Asp-Gly) to aged Wistar rats for 1 month significantly increased activity of membrane enzymes maltase and alkaline phosphatase in epithelial layer of the small intestine. In addition, Vilon significantly increased activity of cytosolic glycyl-L-leucine dipeptidase in the stromal and seromuscular layers of the small intestine in comparison with the control rats not treated with this agent. These findings suggest improvement of trophic and barrier functions of the small intestine and corroborate the hypothesis on the existence of not only epithelial, but also subepithelial enzymatic barrier supporting the enzyme system in the small intestine, especially in aged animals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. V. N. Anisimov, Usp. Sovr. Biol., 120, 146–164 (2000).

    Google Scholar 

  2. L. N. Valenkevich and A. M. Ugolev, in: Biology of Aging [in Russian], Leningrad (1982), pp. 343–369.

  3. L. V. Gromova, S. A. Gusev, V. V. Egorova, et al., Fiziol. Zh. SSSR, 77,No. 11, 82–93 (1991).

    Google Scholar 

  4. Membrane Transport and Hydrolysis: New Data and Hypotheses, Ed. A. M. Ugolev [in Russian], Leningrad (1986).

  5. V. G. Morozov and V. Kh. Khavinson, Peptide Bioregulators: 25 Years of Experimental and Clinical Study [in Russian], St. Petersburg (1996).

  6. Yu. V. Nevmyvak and N. M. Timofeeva, Zh. Evol. Biokhim. Fiziol., 35,No. 11, 330–331 (1999).

    Google Scholar 

  7. Yu. V. Nevmyvak and N. M. Timofeeva, Ros. Fiziol. Zh., 85,No. 12, 1574–1581 (1999).

    Google Scholar 

  8. N. M. Timofeeva, Fiziol. Zh. SSSR, 81,No. 11, 112–124 (1995).

    Google Scholar 

  9. N. M. Timofeeva, L. A. Gordova, V. V. Egorova, et al., Ibid., 82,No. 3, 36–45 (1996).

    Google Scholar 

  10. N. M. Timofeeva, N. N. Iezuitova, V. V. Egorova, and A. A. Nikitina, Mezhdunar. Med. Obz., 1,No. 5, 425–431 (1993).

    Google Scholar 

  11. N. M. Timofeeva, N. N. Iezuitova, V. V. Egorova, et al., Fiziol. Zh. SSSR, 80,No. 11, 91–103 (1994).

    Google Scholar 

  12. A. M. Ugolev, N. N. Iezuitova, and N. M. Timofeeva, Ibid., 78,No. 8, 1–20 (1992).

    Google Scholar 

  13. A. M. Ugolev, V. V. Egorova, N. N. Iezuitova, et al., Ibid., 78,No. 8, 29–37 (1992).

    Google Scholar 

  14. V. Kh. Khavinson, N. M. Timofeeva, V. V. Malinin, et al., Byull. Eksp. Biol. Med., 131,No. 6, 690–693 (2001).

    Google Scholar 

  15. O. H. Lowry, N. J. Rosenbrough, A. L. Farr, and R. J. Randall, J. Biol. Chem., 193, 265–275 (1951).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. North-West Division of the Russian Academy of Medical Sciences, Institute of Bioregulation and Gerontology, Russia

    V. Kh. Khavinson, N. M. Timofeeva, V. V. Malinin, L. A. Gordova & A. A. Nikitina

  2. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg

    V. Kh. Khavinson, N. M. Timofeeva, V. V. Malinin, L. A. Gordova & A. A. Nikitina

Authors
  1. V. Kh. Khavinson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. M. Timofeeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. V. Malinin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. A. Gordova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. A. Nikitina
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Khavinson, V.K., Timofeeva, N.M., Malinin, V.V. et al. Effect of Vilon and Epithalon on Activity of Enzymes in Epithelial and Subepithelial Layers in Small Intestine of Old Rats. Bulletin of Experimental Biology and Medicine 134, 562–564 (2002). https://doi.org/10.1023/A:1022913228900

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1022913228900

Search

Navigation