Skip to main content
SpringerLink
Log in

Perftoran as a Means Modulating the Functional Activity of Liver Macrophages

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experiments on mice showed that perfluorocarbon emulsion Perftoran modulated phagocytic activity of liver macrophages (evaluated by LD50 for Salmonella typhi endotoxin and the rate of elimination of Chinese ink particles from the bloodflow). Phagocytic activity was suppressed for 3 days after injection of 10 mg/kg emulsion, but then increased above the control. Perftoran had a favorable impact on the course of experimental hepatitis in a model experiment based on hyperactivity of Kupffer cells. Perftoran virtually prevented the development of severe hepatitis after prophylactic injection and notably attenuated hepatocyte cytolysis when used as therapeutic mean.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. I. G. Bondarenko, Molecular Mechanisms of Cytolysis Formation in Liver Parenchyma in Acute Viral Hepatitis, Abstract of Cand. Med. Sci. Dissertation, Leningrad (1988).

  2. R. B. Megdesieva, Cellular Immune Response in Clinical Variants of Viral Hepatitis B, Abstract of Cand. Med. Sci. Dissertation, St. Petersburg (1992).

  3. N. N. Pyatovskaya, L. A. Sedova, I. A. Zarembo, and N. A. Lukina, Perfluorocarbon Active Media for Medicine and Biology (New Aspects of Studies) [in Russian], Pushchino (1993), pp. 173–180.

  4. A. Shtel'tsner, Methods of Immunology [in Russian], Moscow (1987), pp. 378–389.

  5. J. Fergula and A. C. Allison, Lancet, 2,No. 8090, 610–611 (1978).

    Google Scholar 

  6. S. O. Heard and J. C. Puyana, Crit. Care Med., 28,No. 4, 1241–1242 (2000).

    Google Scholar 

  7. K. C. Lowe and A. D. Bolland, Biomat. Art. Cells Art. Org., 16,No. 1–3, 459–504 (1988).

    Google Scholar 

  8. J. C. Mathison and R. J. Ulevitch, J. Immunol., 123,No. 5, 2133–2143 (1979).

    Google Scholar 

  9. G. Missale, C. Ferrari, and F. Fiaccadori, Ann. Ital. Med. Int., 10,No. 1, 14–18 (1995).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Infectious Diseases, S. M. Kirov Military Medical Academy, St. Petersburg

    A. Yu. Kovelenov, A. N. Mikhal'tsov & A. N. Malkov

Authors
  1. A. Yu. Kovelenov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. N. Mikhal'tsov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. N. Malkov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kovelenov, A.Y., Mikhal'tsov, A.N. & Malkov, A.N. Perftoran as a Means Modulating the Functional Activity of Liver Macrophages. Bulletin of Experimental Biology and Medicine 134, 551–553 (2002). https://doi.org/10.1023/A:1022905027083

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1022905027083

Search

Navigation