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Preparation of Gd3+-containing polymer complex as a novel magnetic resonance signal-enhancing coating material

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Abstract

This study investigated the suitability of a Gd3+-containing polymer complex used as a magnetic resonance (MR) signal-enhancing coating material. The synthesis of the Gd> 3+-containing polymer complex was done by conjugating N-(2-hydroxyethyl)ethylenediaminetriacetic acid (HEDTA) with poly (styrene-maleic acid) copolymer (SMA), followed by coordinating with Gd3+. The characterizations of FT-IR, NMR and XPS confirmed that HEDTA was covalently attached to SMA and Gd3+-containing polymer complex was formed. Coating such Gd3+-containing polymer complex on the surface of polypropylene (PP) catheter was performed by solution coating method. The results of MR imaging experiments in vitro indicated that the PP catheter coated with this coating material showed strong MR signal in the vicinity of the catheter surface and a clear contrast between the catheter surface and background. Based on these results, a novel MR signal-enhancing coating material, which showed the great potentialities in making catheters for endovascular intervention, visible by MR imaging, can be developed.

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Authors and Affiliations

  1. College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210093, People's, Republic of China

    Jian Guo, Xiqun Jiang, Yong Hu & Changzheng Yang

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  1. Jian Guo
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  2. Xiqun Jiang
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  3. Yong Hu
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  4. Changzheng Yang
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Guo, J., Jiang, X., Hu, Y. et al. Preparation of Gd3+-containing polymer complex as a novel magnetic resonance signal-enhancing coating material. Journal of Materials Science: Materials in Medicine 14, 283–286 (2003). https://doi.org/10.1023/A:1022849227694

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  • DOI: https://doi.org/10.1023/A:1022849227694

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