Abstract
Cytochromes P450 (EC 1.14.14.1) are mixed function oxidases (oxygenases) that can catalyse redox bioconversions of food components. Also, efficacious removal of undesirable components can be achieved using solid-support immobilised enzyme (IME) of a selection from 2700 isoforms of cytochromes P450 (CYP). Cytochromes P450 co-immobilised with other enzymes, or protein receptors, may be used to confer a secondary order of regio- or stereo-specificity of chiral bioconversion: these can be predictable in silico by utilisation of QSARs (quantitative structure/activity relationships).
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Wiseman, A. Limitations of in silico predictability of specificity of co-immobilised cytochromes P450 and mimics in food-bioprocessing. Biotechnology Letters 25, 515–519 (2003). https://doi.org/10.1023/A:1022824015304
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DOI: https://doi.org/10.1023/A:1022824015304