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Effect of Deacetylation on Statmhokinetic Activity of Colchicine Derivatives

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Chemistry of Natural Compounds Aims and scope

Abstract

Screening of colchicine derivatives that was carried out with the tumor culture CaPa in a cytotoxicity test showed that deacetylation decreases the cytotoxicity and increases the mitotic index. Lower toxicity of the deacetylated colchicine derivatives was also noted.

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Authors and Affiliations

  1. Republic Oncology Scientific Center, Ministry of Health, Republic of Uzbekistan, Tashkent

    Z. M. Enikeeva & D. Sh. Nurullaeva

  2. A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent

    N. N. Kuznetsova & Z. S. Khashimova

Authors
  1. Z. M. Enikeeva
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  2. D. Sh. Nurullaeva
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  3. N. N. Kuznetsova
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  4. Z. S. Khashimova
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Enikeeva, Z.M., Nurullaeva, D.S., Kuznetsova, N.N. et al. Effect of Deacetylation on Statmhokinetic Activity of Colchicine Derivatives. Chemistry of Natural Compounds 38, 595–597 (2002). https://doi.org/10.1023/A:1022655208775

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  • DOI: https://doi.org/10.1023/A:1022655208775

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