Skip to main content
SpringerLink
Log in

Synthesis and Structure of Pinostrobin Oxime and Its Biological Activity

  • Published:
Chemistry of Natural Compounds Aims and scope

Abstract

Reaction of pinostrobin with hydroxylamine and hydrazine formed the corresponding oxime and hydrazone with retention of the γ-pyrone ring. The structures of the modified pinostrobin derivatives were established using PMR, 13C NMR, mass spectrometry, and X-ray analysis of pinostrobin oxime. Experiments in vivo revealed high hepatoprotective activity for pinostrobin oxime.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. A. Aitmambetov, V. P. Khilya, and A. Kubzheterova, Khim. Prir. Soedin., 37 (2000).

  2. V. P. Khilya, A. Aitmambetov, and A. Kubzheterova, Khim. Prir. Soedin., 40 (2000).

  3. V. P. Khilya, I. P. Kupchevskaya, and L. G. Grishko, Nitrogeneous Heterocycles and Alkaloids [in Russian], V. G. Kartsev and G. A. Tolstikov, eds., Iridium Press, Moscow (2001), Vol. 1, p. 147.

    Google Scholar 

  4. F. H. Allen, O. Kennard, D. G. Watson, L. Brammer, A. G. Orpen, and R. Taylor, J. Chem. Soc., Perkin Trans. 2, S1 (1987).

    Google Scholar 

  5. V. I. Yamovoi, E. A. Kul´magambetova, A. T. Kulyyasov, K. M. Turdybekov, and S. M. Adekenov, Khim. Prir. Soedin., 361 (2001).

  6. M. Z. Shoja, Kristallografiya, 189, 89 (1989).

    Google Scholar 

  7. V. I. Yamovoi, E. A. Kul´magambetova, A. T. Kulyyasov, K. M. Turdybekov, and S. M. Adekenov, Phytochemistry for Development of a Domestic Pharmaceutical Industry [in Russian], Kararganda (2000), p. 108.

  8. L. F. Fieser and M. Fieser, Reagents for Organic Synthesis, Wiley, New York (1967).

    Google Scholar 

  9. S. M. Adekenov, A. Kh. Tokpaev, E. A. Kul´magambetova, T. S. Seitembetov, and L. N. Pribytkova, Kazakhstan Pat. No. 5696 (1998).

  10. V. V. Men´shikov and L. N. Dilektorskaya, Laboratory Methods of Clinical Research. Handbook [in Russian], Meditsina, Moscow (1987).

    Google Scholar 

  11. W. Lloyd, Handbook of Applied Statistics, Finansy i Statistika, Moscow (1985).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Phytochemistry, Ministry of Education and Science of the Republic of Kazakhstan, Karaganda, ul. M. Gazalieva 4

    E. A. Kul'magambetova, V. I. Yamovoi, D. D. Kusainova, R. N. Pak, A. T. Kulyyasov, K. M. Turdybekov, S. M. Adekenov & Yu. V. Gatilov

Authors
  1. E. A. Kul'magambetova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. I. Yamovoi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. D. Kusainova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. N. Pak
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. T. Kulyyasov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. M. Turdybekov
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S. M. Adekenov
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yu. V. Gatilov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kul'magambetova, E.A., Yamovoi, V.I., Kusainova, D.D. et al. Synthesis and Structure of Pinostrobin Oxime and Its Biological Activity. Chemistry of Natural Compounds 38, 527–531 (2002). https://doi.org/10.1023/A:1022622301506

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1022622301506

Search

Navigation