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Sperm Creatine Kinase Activity in Normospermic and Oligozospermic Hungarian Men

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Abstract

Purpose: Our purpose was to measure sperm creatine phosphokinase (CK) activity, which reflects cytoplasmic retention in immature spermatozoa, in normospermic and oligozospermic Hungarian men.

Methods: A study of 109 randomly selected men in a university-based andrology laboratory was done.

Results: CK activity differed between normospermic and oligozospermic men (0.21 ± 0.02 vs. 1.19 ± 0.15 CK IU/10 8 sperm; n = 56 and n = 53; mean ± standard error of the mean, respectively). There was an inverse correlation between sperm concentration and CK activity (r = −0.70; n = 109). However, 28% of men in the range with less than 10 million sperm/ml had normal sperm CK activity (below the mean + 2 standard deviations of the group with greater than 30 × 10 6 sperm/ml), whereas 36% of men in the group with 20–30 million sperm/ml and 5% in the group with greater than 30 million sperm/ml had elevated CK activities, indicating that the incidence of mature and immature spermatozoa in specimens is independent from the sperm concentrations.

Conclusions: The improved facility of sperm CK activity measurements, compared with sperm concentrations, in the assessment of sperm maturity was confirmed in a Hungarian population. The CK measurements aid the selection of the most efficient treatment for couples with male-factor or unexplained infertility, particularly when considering the options of intrauterine insemination, varicocelectomy followed by a waiting period, or ovulation workup/induction in wives of men who are oligozospermic but may have fertile sperm.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Albert Szent-Györgyi Medical University, Semmelweiss-utca 1, Szeged, Hungary

    Anna Gergely, Janos Szöllösi, Gyorgy Falkai, Bela Resch & Laszlo Kovacs

  2. Sperm Physiology Laboratory, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut

    Gabor Huszar

Authors
  1. Anna Gergely
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  2. Janos Szöllösi
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  3. Gyorgy Falkai
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  4. Bela Resch
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  5. Laszlo Kovacs
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  6. Gabor Huszar
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Gergely, A., Szöllösi, J., Falkai, G. et al. Sperm Creatine Kinase Activity in Normospermic and Oligozospermic Hungarian Men. J Assist Reprod Genet 16, 35–40 (1999). https://doi.org/10.1023/A:1022545612784

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  • DOI: https://doi.org/10.1023/A:1022545612784

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