Skip to main content
SpringerLink
Log in

Brain Sexual Differentiation and Gonadotropins Secretion in the Rat

  • Published:
Cellular and Molecular Neurobiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

REFERENCES

  • Aubert, M. L., Begeot, M., Winiger, B. P., Morel, G., Sizonenko, P. C., and Dubois, P. M. (1985). Ontogeny of hypothalamic luteinizing hormone-releasing hormone (GnRH) and pituitary GnRH receptors in fetal and neonatal rats. Endocrinology 116:1565–1576.

    Google Scholar 

  • Ayoub, D. M., Greenough, W. T., and Juraska, J. M. (1983). Sex differences in dendritic structure in the preoptic area of the juvenile macaque monkey brain. Science 219:197–198.

    Google Scholar 

  • Barraclough, C. A. (1967). Modifications in reproductive function after exposure to hormones during the prenatal and early postnatal period. In Martini, L. and Ganong, W. F. (eds.), Neuroendocrinology, Academic Press, New York, pp. 61–99.

    Google Scholar 

  • Barraclough, C. A., and Turgeon, J. L. (1974). Further studies of the hypothalamo-hypophyseal-gonadal axis of the androgen-sterilized rat. In Forest, M. G. and Bertrand, J. (eds.), Endocrinologie Sexuelle de la Periode Perinatale, INSERM, Paris, pp. 339–357.

    Google Scholar 

  • Beck, W., Hancke, J. L., and Wuttke, W. (1978). Increased sensitivity of dopaminergic inhibition of luteinizing hormone release in immature and castrated female rats. Endocrinology 102:837–843.

    Google Scholar 

  • Becú de Villalobos, D., and Lacau de Mengido, I. M. (1990). Control hormonal del desarrollo puberal en la rata hembra. Acta Physiol. Pharmacol. Latinoam. 40:1.

    Google Scholar 

  • Becú de Villalobos, D., Lux, V. A. R., Lacau de Mengido, I. M., and Libertun, C. (1984). Sexual differences in the serotoninergic control of prolactin and luteinizing hormone secretion in the rat. Endocrinology 115:84–89.

    Google Scholar 

  • Becú-Villalobos, D., and Libertun, C. (1986). Ontogenesis of 3(H) serotonin binding sites in the hypothalamus of the female rat: Relation to serotonin induced LH release in moxestrol pretreated rats. Dev. Brain Res. 25:111–116.

    Google Scholar 

  • Becú-Villalobos, D., Lacau de Mengido, I. M., and Libertun, C. (1989). Developmental changes in FSH secretion induced by 5-hydroxytryptophan, naloxone and haloperidol in male and female rats. Dev. Brain Res. 47:181–186.

    Google Scholar 

  • Becú-Villalobos, D., Lacau-Mengido, I. M., and Libertun, C. (1990a). Ontogenic studies of the neural control of the adenohypophyseal hormones in the rat: Gonadotropins. Cell. Mol. Neurobiol. 10:473–484.

    Google Scholar 

  • Becú-Villalobos, D., Lacau-Mengido, I. M., and Libertun, C. (1990b). Sexual differentiation of the brain is involved in 5-hydroxytryptophan-and naloxone-induced FSH release in the infantile rat. Neuroendocrinol. Lett. 12:435–442.

    Google Scholar 

  • Blank, M. S., Panerai, A. E., and Friesen, H. G. (1979). Opioid peptides modulate luteinizing hormone secretion during sexual maturation. Science 203:1129–1131.

    Google Scholar 

  • Bloch, G. J., and Mills, R. (1995). Prepubertal testosterone treatment of neonatally gonadectomized male rats: Defeminization and masculinization of behavioral and endocrine function in adulthood. Neurosci. Biobehav. Rev. 19:187–200.

    Google Scholar 

  • Bloch, G. J., Mills, R., and Gale, S. (1995b). Prepubertal testosterone treatment of female rats: Defeminization of behavioral and endocrine function in adulthood. Neurosci. Biobehav. Rev. 19:177–186.

    Google Scholar 

  • Bonsall, R. W., Zumpe, D., and Michael, R. P. (1990). Comparisons of the nuclear uptake of [3H]-testosterone and its metabolites by the brain of male and female macaque fetuses at 122 days or gestation. Neuroendocrinology 51:474–480.

    Google Scholar 

  • Bourguignon, J.-P., and Franchimont, P. (1984). Puberty related increase in episodic LHRH release from rat hypothalamus in vitro. Endocrinology 114:1941–1943.

    Google Scholar 

  • Campbell, C. S., and Schwartz, N. B. (1977). Steroid feedback regulation of luteinizing hormone and follicle-stimulating hormone secretion rats in male and female rats. J. Toxicol. Environ. Health 3:61–95.

    Google Scholar 

  • Chan, V., Clayton, R., Knox, G., and Catt, K. J. (1981). Ontogeny of pituitary GnRH receptors in the rat. Endocrinology 108:2086–2092.

    Google Scholar 

  • Chiappa, S. A., and Fink, G. (1977). Releasing factor and hormonal changes in the hypothalamic-pituitary-gonadotrophin and-adrenocorticotrophin systems before and after birth and puberty in male, female and adrogenized female rats. J. Endocrinol. 72:211–224.

    Google Scholar 

  • Clough, R. W., Hoffman, G. E., and Sladek, C. D. (1988). Peripubertal development of noradrenergic stimulation of luteinizing hormone-releasing hormone neurosecretion in vitro. Brain Res. 446:121–132.

    Google Scholar 

  • Dalkin, A. C., Bourne, G. A., Pieper, D. R., Regiani, S., and Marshall, J. C. (1981). Pituitary and gonadal gonadotropin-releasing hormone receptors during sexual maturation in the rat. Endocrinology 108:1658–1664.

    Google Scholar 

  • Damassa, D. A., Rabii, J., and Sawyer, C. H. (1983). Responses of serum LH and FSH to the removal of steroid feedback inhibition. Neuroendocrinology 37:122–130.

    Google Scholar 

  • Debeljuk, L., Arimura, A., and Schally, A. V. (1972a). Studies on the pituitary responsiveness to luteinizing hormone-releasing hormone (LHRH) in intact male rats at different ages. Endocrinology 90:585–589.

    Google Scholar 

  • Debeljuk, L., Arimura, A., and Schally, A. V. (1972b). Pltuitary responsiveness to LH-releasing hormone in intact female rats at different ages. Endocrinology 90:1499.

    Google Scholar 

  • Demling, J., Fuchs, E., Baumert, H., and Wuttke, W. (1985). Preoptic catecholamine, GABA and glutamate release in ovariectomised and ovariectomised oestrogen-primed rat utilizing a push-pull cannula technique. Neuroendocrinology 41:212–218.

    Google Scholar 

  • DePaolo, L. V., and Negro-Vilar, A. (1982). Estrogenic feminization of the LH response to orchidectomy in the rat: Evidence for a hypothalamic site of action. Neuroendocrinology 34:104–111.

    Google Scholar 

  • Diaz-Torga, G., Becú-Villalobos, D., Lacau de Mengido, I. M., and Libertun, C. (1992). Sexual and ontogenic differences in K+ induced gonadotropins and prolactin release in vitro. Dev. Brain Res. 70:103–108.

    Google Scholar 

  • Dohler, K. D. (1991). The pre-and postnatal influence of hormones and neurotransmitters on sexual differentiation of the mammalian hypothalamus. Int. Rev. Cyt. 131:1–57.

    Google Scholar 

  • Dohler, K. D., and Wuttke, W. (1974). Serum LH, FSH, prolactin and progesterone from birth to puberty in female and male rats. Endocrinology 94:1003–1008.

    Google Scholar 

  • DonCarlos, L. L., McAbee, M., Ramer-Quinn, D. S., and Stancik, D. M. (1995). Estrogen receptor mRNA levels in the proptic area of neonatal rats are responsive to hormone manipulation. Dev. Brain Res. 84:253–260.

    Google Scholar 

  • Dorner, G. (1981). Sexual differentiation of the brain. Vit. Horm. 38:325–381.

    Google Scholar 

  • Duncan, J. A., Dalkin, A. C., Barkan, A., Regiani, S., and Marshall, J. C. (1983). Gonadal regulation of pituitary gonadotropin-releasing hormone receptors during sexual maturation in the rat. Endocrinology 113:2238–2236.

    Google Scholar 

  • Dutlow, C. M., Rachman, J., Jacobs, T. W., and Millar, R. P. (1992). Prepubertal increases in gonadotropin-releasing hormone mRNA, gonadotropin-releasing hormone precursor, and subsequent maturation of precursor processing in male rats. J. Clin. Invest. 90:2496–2501.

    Google Scholar 

  • Dyer, R. G., Grossmann, R., Mansfield, D., Diez-Guerra, F. J., Ricknell, R. J., and Hollingsworth, S. (1988). Opioid peptides inhibit noradrenergic transmission in the preoptic area to block LH secretion: Evidence from neonatally androgenized rats. Brain Res. Bull. 20:721–727.

    Google Scholar 

  • Fink, G., and Henderson, S. R. (1977). Steroids and pituitary responsiveness in female, androgenized female and male rats. J. Endocrinol. 73:157–164.

    Google Scholar 

  • Frager, M., Duncan, J., Pieper, D., Tonetta, S., and Marshall, J. C. (1980). Regulation of pituitary GnRH receptors by GnRH and gonadal steroids. Clin. Res. 28:2591–2598.

    Google Scholar 

  • Gay, V. L., and Midgley, A. R. (1969). Response of the adult rat to orchidectomy and ovariectomy as determined by LH radioimmunoassay. Endocrinology 84:1359–1364.

    Google Scholar 

  • Gay, V., and Midgley, A. R. (1977). A sex-related pattern of gonadotropin secretion in the castrated rat: Effects of changing the inhibitory steroid on pituitary LH content. Biol. Reprod. 16:527–535.

    Google Scholar 

  • Grady, R. R. (1986). Effect of neonatal treatment with the sex-opposite steroid on gonadotropin responsiveness in rats. Neuroendocrinology 43:322–330.

    Google Scholar 

  • Grossmann, R., Diez-Guerra, F. J., Mansfield, S., and Dyer, R. G. (1987). Neonatal testosterone modifies LH secretion in the adult female rat by altering the opioid-noradrenergic interaction in the medial preoptic area. Brain Res. 415:205–210.

    Google Scholar 

  • Hammer, R. P. (1985). The sex hormone-dependent development of opiate receptors in the rat medial preoptic area. Brain Res. 360:65–74.

    Google Scholar 

  • Handa, R. J., Condon, T. P, Whitmoyer, D. I., and Gorski, R. A. (1986). Gonadotropin secretion following intraventricular norepinephrine infusion into neonatally androgenised female rats. Neuroendocrinology 43:269–272.

    Google Scholar 

  • Hompes, P. G. A., Vermes, I., Tilders, F. J. H., and Schoemaker, J. (1982). In vitro release of LHRH from the hypothalamus of female rats during prepubertal development. Neuroendocrinology 35:8–12.

    Google Scholar 

  • Hong, J. S., Yoshikawa, K., and Lamartiniere, C. A. (1982). Sex-related difference in the rat pituitary (Met5)-enkephalin level altered by gonadectomy. Brain Res. 251:380–383.

    Google Scholar 

  • Honma, K., Hohn, K. G., and Wuttke, W. (1979). Involvement of catecholamines in eliciting LH peaks in 15-day-old female rats: Effects of treatment with prolactin. Brain Res. 75:271–279.

    Google Scholar 

  • Ieri, T., Chen, H. T., and Meites, J. (1979). Effects of morphine and naloxone on serum levels of luteinizing hormone and prolactin in prepubertal male and female rats. Neuroendocrinology 29:288–292.

    Google Scholar 

  • Jakubowski, M., Blum, M., and Roberts, J. L. (1991). Postnatal development of gonadotropin-releasing hormone and cyclophilin gene expression in the female and male rat brain. Endocrinology 128:2702–2708.

    Google Scholar 

  • Justo, S. N., Rossano, G. L., Szwarcfarb, B., Rubio, M. C., and Moguilevsky, J. A. (1989). Effect of serotoninergic system on FSH secretion in male and female rats: Evidence for stimulatory and inhibitory actions. Neuroendocrinology 50:382–386.

    Google Scholar 

  • Kalra, S. P., and Kalra, P. S. (1981). Neural regulation of luteinizing hormone secretion in the rat. Endocr. Rev. 4:311–351.

    Google Scholar 

  • Kalra, S. P., and Kalra, P. S. (1989). Do testosterone and estradiol-17B enforce inhibition or stimulation of luteinizing hormone-releasing hormone secretion? Biol. Reprod. 41:559–570.

    Google Scholar 

  • Lacau de Mengido, I. M., Becú-Villalobos, D., and Libertun, C. (1987). Sexual differences in the dopaminergic control of LH secretion in the developing rat. Dev. Brain Res. 35:91–95.

    Google Scholar 

  • Lacau de Mengido, I. M., Becú-Villalobos, D., Diaz, G., and Libertun, C. (1989). Chronic activation of dopamine receptors in the female infantile rat: effect on hypophyseal hormones and on the onset of puberty. Endocrinology 124:746–753.

    Google Scholar 

  • Lacau-Mengido, I. M., Becú-Villalobos, D., Thyssen, S. M., Rey, E. B., Lux-Lantos, V. A. R., and Libertun, C. (1993). Antidopaminergic-induced hypothalamic LHRH release and pituitary gonadotrophin secretion in 12 day-old female and male rats. J. Neuroendocrinol. 5:705–709.

    Google Scholar 

  • Leadem, C. A., and Kalra, S. P. (1985). Effects of endogenous opioid peptides and opiates on luteinising hormone and prolactin secretion in ovariectomised rats. Neuroendocrinology 41:342–352.

    Google Scholar 

  • Libertun, C., Timiras, P. S., and Kragt, C. L. (1973). Sexual differences in the hypothalamic cholinergic system before and after puberty. Luducrory effect of testosterone. Neuroendocrinology 12:73–85.

    Google Scholar 

  • Lookingland, K. J., Wise, P. M., and Barraclough, C. A. (1981). Failure of the hypothalamic noradrenergic system to function in androgen-sterilized rats. Biol. Reprod. 27:268–281.

    Google Scholar 

  • Lookingland, K. J., Wise, P. M., and Barraclough, C. A. (1982). Failure of the hypothalamic noradrenergic system to function in adult androgen-sterilized rats. Biol. Reprod. 27:268–281.

    Google Scholar 

  • MacKinnon, P. C. B., and Mattock, J. (1976). The effects of handling on episodic release of LH in immature rats. Ann. Biol. Anim. Biophys. 16:345–348.

    Google Scholar 

  • MacKinnon, P. C. B., Mattock, J., and Ter Haar, M. B. (1976). Serum gonadotropin levels during development in male, female, and androgenized female rats and the effect of general disturbance on high luteinizing hormone levels. J. Endocrinol. 70:361–371.

    Google Scholar 

  • Mennin, S. P., Kubo, K., and Gorski, R. A. (1974). Pituitary responsiveness to luteinizing hormone-releasing factor in normal and androgenized female rats. Endocrinology 95:412–416.

    Google Scholar 

  • Moguilevsky, J. A., Faigon, M. R., Scacchi, P., and Szwarcfarb, B. (1979). Effect of castration on serum gonadotropin levels in androgenized male and female rats. Neuroendocrinology 29:323–328.

    Google Scholar 

  • Moguilevsky, J., Faigon, M. R., Scacchi, P., and Szwarcfarb, B. (1987). Role of sexual differentiation of the hypothalamus in the differential effect of the serotoninergic system on LH in prepubertal male and female rats. Neuroendocrinology 45:274–277.

    Google Scholar 

  • Naish, S. J., Brawer, J., Robaire, B., and Ruf, K. B. (1986). Changes in the dynamics of luteinizing hormone-releasing hormone-stimulated secretion of luteinizing hormone during sexual maturation of female rats. Biol. Reprod. 34:549–557.

    Google Scholar 

  • Ojeda, S. R., and Urbanski, H. F. (1994). Puberty in the rat. In Knobil, E., and Neill, J. (eds.), The Physiology of Reproduction, Raven Press, New York, pp. 363–409.

    Google Scholar 

  • Ojeda, S. R., Jameson, H. E., and Mc Cann, S. M. (1977). Developmental changes in pituitary responsiveness to luteinizing-hormone releasing hormone (LHRH) in the female rat: Ovarian adrenal influences during the infantile period. Endocrinology 100:440–451.

    Google Scholar 

  • Ortmann, O., Merelli, F., Stojilkovic, S. S., Schultz, K. D., Emons, G., and Catt, K. J. (1994). Modulation of calcium signaling and LH secretion by progesterone in pituitary gonadotrophs and clonal pituitary cells. J. Steroid Biochem. Mol. Biol. 48:47–54.

    Google Scholar 

  • Petersen, S. L., and Barraclough, C. A. (1986). Effect of naloxone and morphine on LH and prolactin release in androgen-sterilized rats. Neuroendocrinology 44:84–88.

    Google Scholar 

  • Pinilla, L., Tena-Sempere, M., and Aguilar, E. (1994). Effect of LHRH, naloxone and N-methyl-D-aspartic acid on serum gonadotropin concentrations in neonatally estrogenized female rats. Neuroendocrinol. Lett. 16:233–239.

    Google Scholar 

  • Savoy-Moore, R. T., Schwartz, N. B., Duncan, J., and Marshall, J. C. (1980). Pituitary gonadotropin-releasing hormone receptors during the rat estrous cycle. Science 209:942–944.

    Google Scholar 

  • Schulz, R., Wilhelm, A., Pirke, K. M., and Herz, A. (1985). Sex-dependent endorphinergic and adrenergic control mechanisms of luteinizing hormone secretion in immature rats. Acta Endocrinol. 109:198–203.

    Google Scholar 

  • Simerly, R. B., Swanson, L. W., and Gorski, R. A. (1984). Demonstration of a sexual dimorphism in the distribution of serotonin immunoreactive fibers in the medial preoptic nucleus of the rat. J. Comp. Neurol. 225:151–166.

    Google Scholar 

  • Steger, R. W., and Morgen, W. (1985). Dopaminergic control of pituitary hormone release. In Steger, R. W. and Johns, A. (eds.), Handbook of Pharmacologic Methodologies for the Study of the Neuroendocrine System, CRS Press, Boca Raton, FL, pp. 65–108.

    Google Scholar 

  • Stojilkovic, S. S., Reinhart, J., and Catt, K. J. (1994). Gonadotropin-releasing hormone receptors: structure and signal transduction pathways. Endoc. Rev. 15:462–499.

    Google Scholar 

  • Sylvester, P. W., Sarkar, D. K., Briski, K. P., and Meites, J. (1985). Relation of gonadal hormones to differential LH response to naloxone in prepubertal male and female rats. Neuroendocrinology 40:165–170.

    Google Scholar 

  • Tomic, M., Cesnjaj, M., Catt, K. J. and Stojilkovic, S. S. (1994). Developmental and physiological aspects of Ca2+ signaling in agonist-stimulated pituitary gonadotrophs. Endocrinology 135:1762–1771.

    Google Scholar 

  • Van Vugt, D. A., Sylvester, P. W., Aylsworth, C. F., and Meites, J. (1982). Counteraction of gonadal steroid inhibition of luteinising hormone release by naloxone. Neuroendocrinology 33:261–264.

    Google Scholar 

  • Vreeburg, J. T. M., van der Vaart, P. D. M., and Van der Schoot, P. (1977). Prevention of central defeminization but not masculinization in male rats by inhibition neonatally of oestrogen biosynthesis. J. Endocrinol. 74:375–382.

    Google Scholar 

  • Wray, S., and Gainer, H. (1987). Effect of neonatal gonadectomy on postnatal development in rat LHRH cell subtypes in male and female rats. Neuroendocrinology 45:413–419.

    Google Scholar 

  • Wuttke, W., Honma, K., Lamberts, S. W. J., and Hohn, K. G. (1980). The role of monoamines in female puberty. Fed. Proc. 39:2378-2383

    Google Scholar 

  • Yamamoto, M., Diebel, N. D., and Bogdanove, E. M. (1970). Analysis of initial and delayed effects of orchidectomy and ovariectomy on pituitary and serum LH levels in adult and immature rats. Endocrinology 86:1102-1111

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Instituto de Biología y Medicina Experimental—CONICET, Vuelta de Obligado 2490, 1428, Buenos Aires, Argentina

    Damasia Becú-Villalobos, Arturo González Iglesias, Graciela Díaz-Torga, Pablo Hockl & Carlos Libertun

Authors
  1. Damasia Becú-Villalobos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Arturo González Iglesias
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Graciela Díaz-Torga
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pablo Hockl
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Carlos Libertun
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Becú-Villalobos, D., Iglesias, A.G., Díaz-Torga, G. et al. Brain Sexual Differentiation and Gonadotropins Secretion in the Rat. Cell Mol Neurobiol 17, 699–715 (1997). https://doi.org/10.1023/A:1022542221535

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1022542221535

Search

Navigation