Abstract
This study investigated the way in which feeding rats with two fat sources (olive or sunflower oils) affected electron-transport components and function of mitotic (liver) and postmitotic (heart and skeletal muscle) tissues during ageing. Rats adapted the mitochondrial-membrane-lipid profile to dietary fat throughout the study, suggesting that the benefits to eat either of the two fats might be maintained lifelong. Liver was more resistant to dietary changes and ageing than heart and skeletal muscle, which showed higher levels of coenzyme Q, cytochrome b, and cytochrome a + a 3 with ageing and lower cytochrome c oxidase and complex IV turnover. Dietary fat differentially modulated the response of tissues during ageing, with sunflower oil leading to the highest levels of coenzyme Q and cytochromes b and a + a 3. Since high levels of cytochrome b have been related to increased age, it could be hypothesized that olive oil could lead to less aged mitochondria.
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REFERENCES
Battino, M., Quiles, J. L., Huertas, J. R., Ramírez-Tortosa, M. C., Cassinello, M., Mañas, M., López-Frías, M., and Mataix, J. (2002). J. Bioenerg. Biomembr.
Battino, M., Rugolo, M., Romeo, G., and Lenaz, G. (1986). FEBS Lett. 199, 155–158.
Cairns, C. B., Walther, J., Harken, A. H., and Banerjee, A. (1998). Am. J. Physiol. 274, R1376–R1383.
Capaldi, R. A., Halphen, D. G., Zhang, Y.-Z., and Yanamura, W. (1988). J. Bioenerg. Biomembr. 20, 291–311.
Charnock, J. S., McLennan, P. L., and Abeywardena, M. Y. (1992). Mol. Cell. Biochem. 116, 19–25.
Cooper, J. M., Mann, V. M., and Schapira, A. H. V. (1992). J. Neurol. Sci. 113, 91–98.
Degli Esposti, M., and Lenaz, G. (1982). Biochim. Biophys. Acta 682, 189–200.
Feller, S. E., Gawrisch, K., and MacKerell, A. D. (2002). J. Am. Chem. Soc. 124, 318–326
Fleishcher, S., McIntyre, I. O., and Vidal, J. C. (1979). Methods Enzymol. 55, 32–39.
Gabbita, S. P., Butterfield, D. A., Hensley, K., Shaw, W., and Carney, J. M. (1997). Free Radic Biol. Med. 23, 191–201.
Guarente, L., and Kenyon, C. (2000). Nature 408, 255–262.
Huertas, J. R., Battino, M., Lenaz, G., and Mataix J. (1991a). FEBS Lett. 287, 89–92.
Huertas, J. R., Battino, M., Mataix, F. J., and Lenaz, G. (1991b). Biochem. Biophys. Res. Commun. 181, 375–382.
Kipling, D. (2001). Maturitas 38, 25–38.
Kirwood, T. B. L., and Austad, S. N. (2000). Nature 408, 233–238.
Kumar, V. B., Vyas, K., Buddhiraju, M., Alshaher, M., Flood, J. F., and Morley, J. E. (1999). Life Sci. 65, 1657–1662.
Kwong, L. K., and Sohal, R. S. (2000). Arch. Biochem. Biophys. 373, 16–22.
Lepage, G., and Roy, C. C. (1986). J. Lipid Res. 27, 114–120.
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. G. (1951). J. Biol. Chem. 193, 265–275.
Lutz, M., Alvarado, J., Barraza, P., Bonilla, S., and Luna L. (1999). Lipids 34, S119.
Mataix, J., Quiles, J. L., Huertas, J. R., Battino, M., and Mañas, M. (1998). Free Rad. Biol. Med. 24, 511–521.
Medvedev, J. A. (1990). Biol. Rev. 65, 375–398.
Miquel, J. (1991). Arch. Gerontol. Geriatr. 12, 99–117.
Miquel, J., Ecónomos, A. C., Fleming, J., and Johnson, J. E. (1980). Exp. Gerontol. 15, 575–591.
Miquel, J., Ferrándiz, M. L., De Juan, E., Sevilla, I., and Martínes, M. (1995). Eur. J. Pharmacol. 292, 333–335.
Nicholls, P. (1976). Biochim. Biophys. Acta 430, 30–45.
Ojaimi, J., Masters, C. L., Opeskin, K., McKelvie, P., and Byrne, E. (1999). Mech. Ageing Dev. 111, 39–47.
Quiles, J. L., Huertas, J. R., Mañas, M., Battino, M., and Mataix, J. (1999). Br. J. Nutr. 81, 21–24.
Quiles, J. L., Huertas, J. R., Mañas, M., Ochoa, J. J., Battino, M., and Mataix, J. (2001). J. Bionembr. 33, 127–143.
Sastre, J., Pallardó, F. V., Plá, R., Pellon, A., Juan, G., O'Connor, J. E., Estrella, J. M., Miquel, J., and Viña, J. (1997). Hepatology 24, 1199–1205.
Toth, M. J., and Tchernof, A. (2000). Eur. J. Clin. Nutr. 54, S121–S125.
Vanneste, W. H. (1966). Biochim. Biophys. Acta 113, 175–178.
Wallace, D. W. (1992). Science 256, 628–632.
Yamaoka, S., Ride, R., and Kito, M. (1988). J. Nutr. 118, 290–296.
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Quiles, J.L., Martínez, E., Ibáñez, S. et al. Ageing-Related Tissue-Specific Alterations in Mitochondrial Composition and Function Are Modulated by Dietary Fat Type in the Rat. J Bioenerg Biomembr 34, 517–524 (2002). https://doi.org/10.1023/A:1022530512096
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DOI: https://doi.org/10.1023/A:1022530512096