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Crystal structure of the cytotoxic marine alkaloid 2-bromoleptoclinidinone

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Abstract

2-Bromoleptoclinidinone methanol solvate, C18H8BrN3O·CH4O, crystallizes in the orthorhombic space group Pbca with a = 15.7013(2), b = 7.3308(1), and c = 26.9326(1) Å. The molecule is essentially planar, with the largest deviations occurring at bromine (−0.21 Å), carbonyl oxygen O(l) (+0.19 Å) and in ring-A (C(9) −0.15 Å, C(10) −0.15 Å). Methanol occupies the 1,10-phenanthroline-like metal binding site of the title compound.

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Authors and Affiliations

  1. Department of Chemistry, University of Auckland, Private Bag 92019, Auckland, New Zealand

    Brent S. Lindsay, Allen G. Oliver, Cliff E. F. Rickard & Brent R. Copp

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  1. Brent S. Lindsay
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  2. Allen G. Oliver
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  3. Cliff E. F. Rickard
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  4. Brent R. Copp
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Lindsay, B.S., Oliver, A.G., Rickard, C.E.F. et al. Crystal structure of the cytotoxic marine alkaloid 2-bromoleptoclinidinone. Journal of Chemical Crystallography 28, 645–648 (1998). https://doi.org/10.1023/A:1022421328245

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