Abstract
In the air pouch-type allergic inflammation in rats, we reported that a sustained histamine production in the late phase is induced by a cytokine-like factor, named histamine-production-increasing factor (HPIF) (1). Recently, we found another type of histamine-production-increasing factor in the pouch fluid at the chronic phase of air pouch-type allergic inflammation. Although it did not increase histamine production by itself, it enhanced the HPIF-induced histamine production by rat bone marrow cells. It also increased GM-CSF-induced histamine production. The activity of this factor increased time-dependently from 3 to 7 days after the antigen challenge. Injection of the 5 day pouch fluid sample containing this factor into the pouch 4 h after the antigen challenge increased histamine contents in the pouch fluid at 24 h, indicating that this factor enhances HPIF-induced histamine production in vivo. Biochemical analysis of the 5 day pouch fluid sample indicated that this factor is a heat-labile and trypsin-sensitive protein of which pI value and molecular weight are 7–8 and about 100 kDa, respectively.
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REFERENCES
Hirasawa, N., K. Ohuchi, K. Kawarasaki, M. Watanabe, and S. Tsurufuji. 1989. Occurrence of histamine-production-increasing factor in the post-anaphylactic phase of allergic inflammation. Int. Arch. Allergy Appl. Immunol. 88:386–393.
Endo, Y. 1982. Simultaneous induction of histidine and ornithine decarboxylases and changes in their product amines following the injection of Eschrichia Coli lipopolysaccharide into mice. Biochem. Pharmacol. 31:1643–1647.
Kawaguchi-Nagata, K., T.s Watanabe, A. Yamatodani, M. Inoue, J. Fujita, H. Okamura, T. Tamura, K. Shouji, H. Wada, and Y. Kitamura. 1987. Induction of histidine decarboxylase in non-mast cells in the spleen of mice by injection of Staphylococcal Enterotoxin A. J. Biochem. 102:551–557.
Endo, Y., and M. Nakamura. 1993. Active translocation of platelets into sinusoidal and Disse spaces in the liver in response to lipopolysaccharides, interleukin-1 and tumor necrosis factor. Gen. Pharmacol. 24:1039–1053.
Beaven, M. A., and H. Metzger. 1993. Signal transduction by Fc receptors: the FcεRI case. Immunol. Today 14:222–226.
Dy, M., and B. Lebel. 1983. Skin allografts generate an enhanced production of histamine and histamine-producing cell-stimulating factor (HCSF) by spleen cells in response to T cell mitogens. J. Immunol. 130:2343–2347.
Schneider, E., H. Pollard, F. Lepault, D. Guy-Grand, M. Minkowski, and M. Dy. 1987. Histamine-producing cell-stimulating activity. Interleukin 3 and granulocyte-macrophage colony-stimulating factor induce de novo synthesis of histidine decarboxylase in hemopoietic progenitor cells. J. Immunol. 139:3710–3717.
Dy, M., F. Machavoine, B. Lebel, A. Ichikawa, L. N. Gastinel, and E. Schneider. 1993. Interleukin 3 promotes histamine synthesis in hematopoietic progenitors by increasing histidine decarboxylase mRNA expression. Biochem. Biophys. Res. Commun. 192:167–173.
Endo, Y., T. Kikuchi, Y. Takeda, Y. Nitta, H. Rikiishi, and K. Kumagai. 1992. GM-CSF and G-CSF stimulate the synthesis of histamine and putrescine in the hematopoietic organs in vivo. Immunol. Lett. 33:9–14.
Piquet-Pellorce, C., F. Homo-Delarche, and M. Dy. 1989. Interleukin 1 and/or tumor necrosis factor-α synergize with granulocyte-macrophage colony-stimulating factor to enhance histamine synthesis in hematopoietic cells: role of prostaglandin E2. Eur. J. Immunol. 19:1999–2003.
Hirasawa, N., K. Ohuchi, M. Watanabe, and S. Tsurufuji. 1987. Role of endogenous histamine in postanaphylactic phase of allergic inflammation in rats. J. Pharmacol. Exp. Ther. 24 1:967–973.
Hirasawa, N., Y. Funaba, Y. Hirano, K. Kawarasaki, M. Omata, M. Watanabe, S. Mue, S. Tsurufuji, and K. Ohuchi. 1990. Inhibition by dexamethasone of histamine production in allergic inflammation in rats. J. Immunol. 145:3041–3046.
Hirasawa, N., K. Ohuchi, M. Watanabe, and S. Tsurufuji. 1987. Mechanism of the inhibitory action of cyclooxygenase inhibitors on leukocytes infiltration: involvement of endogenous histamine. Eur. J. Pharmacol. 144:267–275.
Ohuchi, K., N. Hirasawa, M. Watanabe, and S. Tsurufuji. 1985. Pharmacological analysis of the vascular permeability response in the anaphylactic phase of allergic inflammation. Eur. J. Pharmacol. 117:337–345.
Tsurufuji, S., S. Yoshino, and K. Ohuchi. 1982. Induction of an allergic air-pouch inflammation in rats. Int. Arch. Allergy Appl. Immunol. 69:189–198.
Shore, P. A., A. Burkhalter, and V. H. Cohn. 1959. A method for the fluorometric assay of histamine in tissues. J. Pharmacol. Exp. Ther. 127:182–186.
Watanabe, T., Y. Taguchi, K. Sasaki, K. Tsuyama, and Y. Kitamura. 1981. Increase in histidine decarboxylase activity in mouse skin after application of the tumor promotor tetradecanoylphorbol acetate. Biochem. Biophys. Res. Commun. 100:427–432.
Edamatsu, T., Y.-Q. Xiao, J. Tanabe, S. Mue, and K. Ohuchi. 1997. Induction of neutrophil chemotactic factor production by staurosporine in rat peritoneal neutrophils. Br. J. Pharmacol. 121:1651–1658.
Schneider, E., C. Piquet-Pellorce, and M. Dy. 1990. New role for histamine in interleukin-3-induced proliferation of hematopoietic stem cells. J. Cell. Physiol. 143:337–343.
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Hirasawa, N., Shiraishi, M., Oikawa, S. et al. Increase in Histamine Production by Inflammatory Exudate in the Chronic Phase of Allergic Inflammation in Rats. Inflammation 22, 471–482 (1998). https://doi.org/10.1023/A:1022393926234
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DOI: https://doi.org/10.1023/A:1022393926234