Abstract
The following biologically active diiodohalides of organic cations were studied: N-cetylpyridinium, trimethylbenzylammonium, triethylbenzylammonium, and N,N-dimethylmorpholinium diiodochlorides; N-cetylpyridinium, tetramethylammonium, tetrabutylammonium, and N,N-dimethylmorpholinium diiodobromides; and N,N-dimethylmorpholinium and butyroylcholinium triiodides. A simple and rapid procedure was proposed for the determination of the above compounds; it is based on the conversion of organic diiodohalides into the corresponding triiodides (ε300 nm ≈ 4 × 104; ε370 nm ≈ 2 × 104) in the presence of excess potassium iodide (RSD ≤ 2%). An extraction–spectrophotometric method was developed for the quantitative determination of the biologically active compounds in pharmaceutical dosage forms based on their ion associates with anionic dyes, erythrosine (m min = 1.25–3.30 μg; RSD ≤ 3%) and Bromothymol Blue (m min = 3.85 μg; RSD = 3%), or a cationic dye—1,3-dimethyl-2-(4-morpholinophenyl)azobenzimidazolium phenylsulfate (m min = 2.32–8.26 μg; RSD ≤ 4%). The developed procedures were used for monitoring drug substances in model pharmaceutical preparations (RSD ≤ 4%).
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Chernov'yants, M.S., Gol'eva, V.E. & Pyshchev, A.I. Spectrophotometric Determination of the Polyiodohalides of Organic Nitrogen-Containing Cations. Journal of Analytical Chemistry 58, 139–143 (2003). https://doi.org/10.1023/A:1022302020450
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DOI: https://doi.org/10.1023/A:1022302020450