Skip to main content
SpringerLink
Log in

Solvolysis of 2-Amino-2-thiazoline Derivatives by Aliphatic Amino Alcohols

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The opening of the thiazoline ring upon the action of amino alcohols was studied. The effects of the reagent ratio and structures of the heterocycles and amino alcohols on aminolysis were investigated. A new method was developed for the preparative synthesis of a series of N'-(hydroxyalkyl)-2-guanidinoalkanethiols.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. V. G. Vladimirov, I. I. Krasil′nikov, and O. V. Arapov, Radioprotectors: Structure and Function [in Russian], Naukova Dumka, Kiev (1989).

    Google Scholar 

  2. F. M. Fedoseev, Thiazolines and Thiazines - A New type of Radioprotective Compounds. Questions in Modern Radiation Pharmacology [in Russian], Nauka, Moscow (1980), p. 10.

    Google Scholar 

  3. G. Hendrik and F. Atkinson, J. Med. Chem., 9, 558 (1966).

    Google Scholar 

  4. A. A. Mandrugin, V. M. Fedoseev, M. N. Semenenko, and S. M. Khomutov, Khim. Geterotsikl. Soedin., 1550 (2000).

  5. A. A. Mandrugin, V. M. Fedoseev, S. M. Khomutov, A. A. Rodyunin, and Yu. A. Leshchev, Khim. Geterotsikl. Soedin., 1572 (1987).

  6. N. M. Turkevich and B. I. Shvydkii, Ukr. Khim. Zh., 18, 513 (1952).

    Google Scholar 

  7. W. O. Foye, T. Mickels, R. N. Duval, and T. R. Marshall, J. Med. Chem., 6, 509 (1963).

    Google Scholar 

  8. E. D. Manolov, Farmatsiya, No. 15, 271 (1965).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, 119899, Moscow, Russia

    A. A. Mandrugin, V. M. Fedoseev, O. V. Dubovaya, A. A. Rodyunin & M. N. Semenko

Authors
  1. A. A. Mandrugin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. M. Fedoseev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. V. Dubovaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. A. Rodyunin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. N. Semenko
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mandrugin, A.A., Fedoseev, V.M., Dubovaya, O.V. et al. Solvolysis of 2-Amino-2-thiazoline Derivatives by Aliphatic Amino Alcohols. Chemistry of Heterocyclic Compounds 38, 1382–1388 (2002). https://doi.org/10.1023/A:1022190728686

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1022190728686

Search

Navigation