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Sulfoalkylation of 1,2-Dihydro-3,6-pyridazine- and 2,3-Dihydro-1,4-Phthalazinediones and Their N-Phenyl Derivatives by 1,3-Propanesultone and Bromoalkanesulfonates

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Abstract

When 1,2-dihydropyridazine-3,6-, 2,3-dihydrophthalazine-1,4-, 1-phenyl-1,2-dihydropyridazine-3,6-, and 2-phenyl-2,3-dihydrophthalazine-1,4-diones react with 1,3-propanesultone and bromoalkanesulfonates, depending on the nature of the sulfoalkylating agent in the case of 1,2-dihydropyridazine-3,6- and 2,3-dihydrophthalazine-1,4-diones, either N,O- or O,O1-disulfoalkylated compounds may be formed, while O-monosulfoalkylated reaction products may be formed in the case of the N-phenyl-substituted derivatives of the above-indicated azinediones.

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Authors and Affiliations

  1. Institute of Chemistry, Vilnius, LT-2600, Lithuania

    L. Rastyanite, G. K. Kupyatis, A. Matiyeshka & O. Eicher-Lorka

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  1. L. Rastyanite
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  2. G. K. Kupyatis
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  3. A. Matiyeshka
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  4. O. Eicher-Lorka
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Rastyanite, L., Kupyatis, G.K., Matiyeshka, A. et al. Sulfoalkylation of 1,2-Dihydro-3,6-pyridazine- and 2,3-Dihydro-1,4-Phthalazinediones and Their N-Phenyl Derivatives by 1,3-Propanesultone and Bromoalkanesulfonates. Chemistry of Heterocyclic Compounds 38, 1363–1367 (2002). https://doi.org/10.1023/A:1022182526868

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