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Nitropyridines. 1. Hantzsch Synthesis of Nitropyridines and Their Quaternary Salts

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Previously unknown 1,4-dihydropyridines containing acetyl, amide, benzoyl, ester, and cyano groups together with a nitro group were synthesized with preparative yields by a two-component Hantzsch synthesis based on 2-nitro-1,3-diphenylpropenone and various enamines. The nitrodihydropyridines were aromatized with sodium nitrite in acetic acid. The quaternary salts of low-basicity pyridines were produced with dimethyl sulfate and methyl fluorosulfonate.

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Authors and Affiliations

  1. Omsk State University, Omsk, 644077, Russia

    G. P. Sagitullina, L. V. Glizdinskaya, G. V. Sitnikov & R. S. Sagitullin

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  1. G. P. Sagitullina
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  2. L. V. Glizdinskaya
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  3. G. V. Sitnikov
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  4. R. S. Sagitullin
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Sagitullina, G.P., Glizdinskaya, L.V., Sitnikov, G.V. et al. Nitropyridines. 1. Hantzsch Synthesis of Nitropyridines and Their Quaternary Salts. Chemistry of Heterocyclic Compounds 38, 1336–1341 (2002). https://doi.org/10.1023/A:1022174325051

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