Abstract
Nikant antimicrobial polyamide surgical sutures containing doxycycline were developed. Desorption of the drug into a model medium, “wicking,” and the antibacterial activity of the sutures in vitro and in vivo were investigated. The selected method of modifying the surface of polyamide fibres allows dosed release of the drug into the wound over 10-18 days, which demonstrates the expediency of using Nikant sutures in clinical practice.
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Shkurenko, S.I., Idiatulina, T.S. Nikant Biologically Active Surgical Sutures. Fibre Chemistry 34, 346–349 (2002). https://doi.org/10.1023/A:1022159018362
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DOI: https://doi.org/10.1023/A:1022159018362